Document Detail

Preliminary experience with onyx embolization for the treatment of intracranial dural arteriovenous fistulas.
MedLine Citation:
PMID:  17974618     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND PURPOSE: Onyx was recently approved for the treatment of pial arteriovenous malformations, but its use to treat dural arteriovenous fistulas (DAVFs) is not yet well established. We now report on the treatment of intracranial DAVFs using this nonadhesive liquid embolic agent. MATERIALS AND METHODS: We performed a retrospective analysis of 12 consecutive patients with intracranial DAVFs who were treated with Onyx as the single treatment technique at our institution between March 2006 and February 2007. RESULTS: A total of 17 procedures were performed in 12 patients. In all of the cases, transarterial microcatheterization was performed, and Onyx-18 or a combination of Onyx-18/Onyx-34 was used. Eight patients were men. The mean age was 56 +/- 12 years. Nine patients were symptomatic. There was an average of 5 feeders per DAVF (range, 1-9). Cortical venous reflux was present in all of the cases except for 1 of the symptomatic patients. Complete resolution of the DAVF on immediate posttreatment angiography was achieved in 10 patients. The remaining 2 patients had only minimal residual shunting postembolization, 1 of whom appeared cured on a follow-up angiogram 8 weeks later. The other patient has not yet had angiographic follow-up. Follow-up angiography (mean, 4.4 months) is currently available in 9 patients. There was 1 angiographic recurrence (asymptomatic), which was subsequently re-embolized with complete occlusion of the fistula and its draining vein. There was no significant morbidity or mortality. CONCLUSION: In our experience, the endovascular treatment of intracranial DAVFs with Onyx is feasible, safe, and highly effective with a small recurrence rate in the short-term follow-up.
R G Nogueira; G Dabus; J D Rabinov; C J Eskey; C S Ogilvy; J A Hirsch; J C Pryor
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Publication Detail:
Type:  Journal Article     Date:  2007-11-01
Journal Detail:
Title:  AJNR. American journal of neuroradiology     Volume:  29     ISSN:  1936-959X     ISO Abbreviation:  AJNR Am J Neuroradiol     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2008-01-14     Completed Date:  2008-04-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8003708     Medline TA:  AJNR Am J Neuroradiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  91-7     Citation Subset:  IM    
Division of Interventional Neuroradiology and Endovascular Neurosurgery, Massachusetts General Hospital, Boston, Mass, USA.
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MeSH Terms
Dimethyl Sulfoxide / therapeutic use*
Embolization, Therapeutic / instrumentation*,  methods*
Fibrinolytic Agents / therapeutic use
Intracranial Arteriovenous Malformations / radiography*,  therapy*
Middle Aged
Pilot Projects
Polyvinyls / therapeutic use*
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Fibrinolytic Agents; 0/Onyx copolymer; 0/Polyvinyls; 67-68-5/Dimethyl Sulfoxide

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