Document Detail

Preliminary experience with nesiritide in the pediatric population.
MedLine Citation:
PMID:  15154997     Owner:  NLM     Status:  MEDLINE    
Nesiritide is a recombinant formulation of brain-type natriuretic factor. Preliminary experience in the adult population suggests that nesiritide may be an effective agent in the treatment of decompensated congestive heart failure. Given its physiologic effects, it may be an effective agent in the pediatric population; however, to date, there are no reports regarding its use in infants and children. The authors retrospectively review their experience with nesiritide in 5 pediatric patients. The cohort of 5 patients included a diverse population with 2 patients who were status postcardiothoracic surgery, 2 with adult respiratory distress syndrome, and 1 in the recovery phase from septic shock. Although no direct measurement of cardiac output was feasible as none of the patients had a pulmonary artery catheter, other indicators of increased cardiac output were noted. These included improved peripheral perfusion with warming of the extremities and improvement of peripheral pulses in all of the patients, increased venous saturation in 2 of the patients, and maintenance of or increased urine output despite weaning or discontinuation of diuretics. In 3 of the patients, nesiritide was started as the primary agent to provide a decrease in systemic vascular resistance and augment cardiac output, while in the other 2 patients, nesiritide was used when other vasoactive agents failed to provide the desired effect or resulted in adverse effects.
Julie Marshall; John W Berkenbosch; Pierantonio Russo; Joseph D Tobias
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of intensive care medicine     Volume:  19     ISSN:  0885-0666     ISO Abbreviation:  J Intensive Care Med     Publication Date:    2004 May-Jun
Date Detail:
Created Date:  2004-05-24     Completed Date:  2004-09-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8610344     Medline TA:  J Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  164-70     Citation Subset:  IM    
University of Missouri School of Medicine, Columbia, Missouri 65212, USA.
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MeSH Terms
Child, Preschool
Natriuretic Agents / therapeutic use*
Natriuretic Peptide, Brain / therapeutic use*
Respiratory Insufficiency / drug therapy*
Retrospective Studies
Shock / drug therapy*
Reg. No./Substance:
0/Natriuretic Agents; 114471-18-0/Natriuretic Peptide, Brain

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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