Document Detail

Preliminary experience with inhaled nitric oxide for acute pulmonary hypertension after heart transplantation.
MedLine Citation:
PMID:  7654725     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Substantial interest has developed in the physiologic and therapeutic role of nitric oxide in the last few years. In patients with pulmonary hypertension it appears to be a useful selective pulmonary vasodilator; however, many issues of both staff and patient safety remained unanswered. METHODS: This study examines further safety issues and also presents preliminary clinical experience in patients after orthotopic heart transplantation with pulmonary hypertension and right-sided ventricular failure. RESULTS: Atmospheric levels of nitric oxide and nitrogen dioxide are 100 times less than occupational health standards. When nitric oxide is used at 70 parts per million in the presence of a fraction of inspired oxygen greater than 0.60, nitrogen dioxide levels in the circuit exceed the published short-term exposure limit of the American Conference of Government Industrial Hygienist of 5 parts per million. CONCLUSION: Staff safety appears confirmed, but despite encouraging clinical results, further longer term safety and efficacy studies are indicated.
T J Williams; R F Salamonsen; G Snell; D Kaye; D S Esmore
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation     Volume:  14     ISSN:  1053-2498     ISO Abbreviation:  J. Heart Lung Transplant.     Publication Date:    1995 May-Jun
Date Detail:
Created Date:  1995-10-05     Completed Date:  1995-10-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9102703     Medline TA:  J Heart Lung Transplant     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  419-23     Citation Subset:  IM    
Department of Respiratory Medicine, Alfred Hospital, Melbourne, Australia.
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MeSH Terms
Administration, Inhalation
Heart Transplantation*
Hypertension, Pulmonary / complications,  drug therapy*
Nitric Oxide / administration & dosage*,  analysis,  toxicity
Nitrogen Dioxide / analysis
Reg. No./Substance:
10102-43-9/Nitric Oxide; 10102-44-0/Nitrogen Dioxide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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