Document Detail

Preliminary experience with dexmedetomidine in the treatment of cyclic vomiting syndrome.
MedLine Citation:
PMID:  12845396     Owner:  NLM     Status:  MEDLINE    
Cyclic vomiting syndrome (CVS) is a chronic, recurrent disorder of unknown etiology characterized by episodes of nausea and vomiting lasting hours or days and separated by symptom-free intervals of weeks to months. Although several different therapeutic regimens have been suggested for CVS, there remains no standard, effective regimen. In many cases, management of vomiting episodes includes the use of potent sedatives that induce prolonged durations of sedation and sleep. Dexmedetomidine is an alpha(2) adrenergic agonist with an increased specificity for the alpha(2) versus the alpha(1) receptor when compared with clonidine. Several physiologic effects have been demonstrated with dexmedetomidine including sedation, anxiolysis, analgesia, and blunting of the sympathetic nervous system. We report, for the first time, successful use of dexmedetomidine to treat CVS in 3 pediatric-aged patients. Potential mechanisms for its efficacy and future potential as a therapeutic agent for CVS are discussed.
Tariq A Khasawinah; Alejandro Ramirez; John W Berkenbosch; Joseph D Tobias
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of therapeutics     Volume:  10     ISSN:  1075-2765     ISO Abbreviation:  Am J Ther     Publication Date:    2003 Jul-Aug
Date Detail:
Created Date:  2003-07-07     Completed Date:  2003-11-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9441347     Medline TA:  Am J Ther     Country:  United States    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  IM    
Department of Child Health, University of Missouri, Columbia, Missouri 65212, USA.
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MeSH Terms
Adrenergic alpha-Agonists / therapeutic use*
Child, Preschool
Dexmedetomidine / therapeutic use*
Treatment Outcome
Vomiting / drug therapy*,  physiopathology
Reg. No./Substance:
0/Adrenergic alpha-Agonists; 113775-47-6/Dexmedetomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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