Document Detail


Preliminary evidence for spectral opponency in the suppression of melatonin by light in humans.
MedLine Citation:
PMID:  15076759     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Human adult males were exposed to light from blue light emitting diodes (18 lux; 29 microW/cm) and from clear mercury vapor lamps (450 lux; 170 microW/cm) during night-time experimental sessions. Both conditions suppressed nocturnal melatonin concentrations in blood plasma with the blue light more effective than mercury at melatonin suppression. No additive model incorporating opsin photopigments either alone or in combination could explain the results, but a model incorporating an opponent mechanism was consistent with the present data as well as data from previously published studies.
Authors:
Mariana G Figueiro; John D Bullough; Robert H Parsons; Mark S Rea
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroreport     Volume:  15     ISSN:  0959-4965     ISO Abbreviation:  Neuroreport     Publication Date:  2004 Feb 
Date Detail:
Created Date:  2004-04-12     Completed Date:  2004-06-10     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  313-6     Citation Subset:  IM    
Affiliation:
Lighting Research Center, Rensselaer Polytechnic Institute, 21 Union Street, Troy, NY 12180, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Bodily Secretions / radiation effects*
Circadian Rhythm / physiology,  radiation effects*
Humans
Light*
Lighting
Male
Melatonin / blood,  metabolism,  secretion*
Models, Neurological
Photoreceptor Cells / metabolism,  radiation effects
Pineal Gland / metabolism,  radiation effects
Retinal Ganglion Cells / metabolism,  radiation effects
Rod Opsins / metabolism,  radiation effects
Chemical
Reg. No./Substance:
0/Rod Opsins; 0/melanopsin; 73-31-4/Melatonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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