Document Detail

Preliminary evidence for medication effects on functional abnormalities in the amygdala and anterior cingulate in bipolar disorder.
MedLine Citation:
PMID:  16249909     Owner:  NLM     Status:  MEDLINE    
RATIONALE: Abnormal amygdala and frontocortical responses to emotional stimuli are implicated in bipolar disorder (BD) and have been proposed as potential treatment targets.
OBJECTIVES: The aim of this study was to investigate amygdala and frontocortical responses to emotional face stimuli in BD and the influences of mood-stabilizing medications on these responses.
METHODS: Functional magnetic resonance imaging was performed while 17 BD participants (5 unmedicated) and 17 healthy comparison (HC) participants viewed faces with happy, sad, fearful, or neutral expressions.
RESULTS: The group by stimulus-condition interaction was significant (p<0.01) for amygdala activation, with the greatest effects in the happy face condition. Relative to HC, amygdala increases were greater in unmedicated BD, but lower in medicated BD. Rostral anterior cingulate (rAC) activation was decreased in unmedicated BD compared to HC; however, BD participants taking medication demonstrated rAC activation similar to HC participants.
CONCLUSIONS: Although the sample sizes were small, these preliminary results suggest that BD is associated with increased amygdala and decreased rAC response to emotional faces. The findings also provide preliminary evidence that mood-stabilizing medications may reverse abnormalities in BD in the response of an amygdala-frontal neural system to emotional stimuli.
Hilary P Blumberg; Nelson H Donegan; Charles A Sanislow; Susan Collins; Cheryl Lacadie; Pawel Skudlarski; Ralitza Gueorguieva; Robert K Fulbright; Thomas H McGlashan; John C Gore; John H Krystal
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2005-10-26
Journal Detail:
Title:  Psychopharmacology     Volume:  183     ISSN:  0033-3158     ISO Abbreviation:  Psychopharmacology (Berl.)     Publication Date:  2005 Dec 
Date Detail:
Created Date:  2005-12-05     Completed Date:  2006-01-04     Revised Date:  2014-09-08    
Medline Journal Info:
Nlm Unique ID:  7608025     Medline TA:  Psychopharmacology (Berl)     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  308-13     Citation Subset:  IM    
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MeSH Terms
Amygdala / physiopathology*
Bipolar Disorder / drug therapy*,  physiopathology,  psychology
Facial Expression
Gyrus Cinguli / physiopathology*
Magnetic Resonance Imaging
Middle Aged
Grant Support
K05AA14906-01/AA/NIAAA NIH HHS; K05MH01654/MH/NIMH NIH HHS; K23 MH073708/MH/NIMH NIH HHS; K23 MH073708-01/MH/NIMH NIH HHS; K23 MH073708-02/MH/NIMH NIH HHS; K23 MH073708-03/MH/NIMH NIH HHS; K23 MH073708-04/MH/NIMH NIH HHS; K23 MH073708-05/MH/NIMH NIH HHS; R01 MH070902/MH/NIMH NIH HHS; R01MH070902/MH/NIMH NIH HHS; R01MH69747/MH/NIMH NIH HHS

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