Document Detail


Preliminary evidence for a link between schizophrenia and NMDA-glycine site receptor ligand metabolic enzymes, d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1).
MedLine Citation:
PMID:  16828464     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Preliminary investigations, studying gene expression and biochemical activities of enzymes d-amino acid oxidase (DAAO) and kynurenine aminotransferase-1 (KAT-1), revealed elevated cerebellar KAT-1 and DAAO activities in post-mortem brain samples from schizophrenic versus normal individuals. In addition, we have identified a transcript of DAAO, which was expressed in significantly higher quantities in the diseased cerebellum but not detected in the parietal cortex where DAAO activity is absent.
Authors:
Ranjna Kapoor; Kelly S Y Lim; Alice Cheng; Therese Garrick; Vimal Kapoor
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-07-07
Journal Detail:
Title:  Brain research     Volume:  1106     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  2006 Aug 
Date Detail:
Created Date:  2006-08-09     Completed Date:  2006-11-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  205-10     Citation Subset:  IM    
Affiliation:
Department of Physiology and Pharmacology, School of Medical Sciences, Faculty of Medicine, University of New South Wales, Sydney 2052, Australia. rkapoor@meddent.uwa.edu.au
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MeSH Terms
Descriptor/Qualifier:
Alternative Splicing / genetics
Animals
Cerebellum / enzymology*,  physiopathology
D-Amino-Acid Oxidase / genetics,  metabolism*
Gene Expression Regulation, Enzymologic / physiology
Humans
Ligands
Models, Neurological
Parietal Lobe / enzymology,  physiopathology
Protein Isoforms / genetics,  metabolism
RNA, Messenger / analysis,  metabolism
Rats
Rats, Inbred WKY
Receptors, Glycine / metabolism*
Receptors, N-Methyl-D-Aspartate / metabolism*
Schizophrenia / enzymology*,  physiopathology
Synaptic Transmission / physiology
Transaminases / genetics,  metabolism*
Up-Regulation / physiology
Chemical
Reg. No./Substance:
0/Ligands; 0/Protein Isoforms; 0/RNA, Messenger; 0/Receptors, Glycine; 0/Receptors, N-Methyl-D-Aspartate; EC 1.4.3.3/D-Amino-Acid Oxidase; EC 2.6.1.-/Transaminases; EC 2.6.1.7/kynurenine-oxoglutarate transaminase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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