| Preliminary evidence for a cocaine-induced embryopathy in mice. | |
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MedLine Citation:
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PMID: 2330587 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The current dramatic increase in illicit cocaine use by individuals during their reproductive years has heightened concerns over the possible adverse effects of maternal cocaine abuse during pregnancy. To address such concerns, the teratogenic effects of cocaine hydrochloride were investigated in two inbred mouse strains (SWV and DBA/2J). The drug was administered on either Gestational Days 6-8 or 8-10 by intraperitoneal injection, and the progeny examined on Gestational Day 18. While treatment with increasing concentrations of the drug did not adversely affect the rates of implantation, resorption, maternal weight gain, or fetal weights, there was a dose-related effect on the frequency of congenital malformations. This was consistently observed in both mouse strains. The types of congenital defects observed in the mouse fetuses bore a striking similarity to those reported in the clinical literature, including cardiovascular defects, limb abnormalities, and genitourinary malformations. |
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Authors:
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R H Finnell; S Toloyan; M van Waes; P W Kalivas |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Toxicology and applied pharmacology Volume: 103 ISSN: 0041-008X ISO Abbreviation: Toxicol. Appl. Pharmacol. Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-05-25 Completed Date: 1990-05-25 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0416575 Medline TA: Toxicol Appl Pharmacol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 228-37 Citation Subset: IM |
Affiliation:
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Department of Veterinary and Comparative Anatomy, College of Veterinary Medicine, Washington State University, Pullman 99164. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abnormalities, Drug-Induced
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etiology* Animals Birth Weight / drug effects Cocaine* / toxicity Dose-Response Relationship, Drug Female Fetal Diseases / chemically induced* Litter Size / drug effects Mice Mice, Inbred DBA Models, Biological Pregnancy Prenatal Exposure Delayed Effects* Substance-Related Disorders / complications* |
| Grant Support | |
ID/Acronym/Agency:
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ES04326/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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50-36-2/Cocaine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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