Document Detail


Preliminary evidence for a cocaine-induced embryopathy in mice.
MedLine Citation:
PMID:  2330587     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The current dramatic increase in illicit cocaine use by individuals during their reproductive years has heightened concerns over the possible adverse effects of maternal cocaine abuse during pregnancy. To address such concerns, the teratogenic effects of cocaine hydrochloride were investigated in two inbred mouse strains (SWV and DBA/2J). The drug was administered on either Gestational Days 6-8 or 8-10 by intraperitoneal injection, and the progeny examined on Gestational Day 18. While treatment with increasing concentrations of the drug did not adversely affect the rates of implantation, resorption, maternal weight gain, or fetal weights, there was a dose-related effect on the frequency of congenital malformations. This was consistently observed in both mouse strains. The types of congenital defects observed in the mouse fetuses bore a striking similarity to those reported in the clinical literature, including cardiovascular defects, limb abnormalities, and genitourinary malformations.
Authors:
R H Finnell; S Toloyan; M van Waes; P W Kalivas
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Toxicology and applied pharmacology     Volume:  103     ISSN:  0041-008X     ISO Abbreviation:  Toxicol. Appl. Pharmacol.     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-05-25     Completed Date:  1990-05-25     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0416575     Medline TA:  Toxicol Appl Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  228-37     Citation Subset:  IM    
Affiliation:
Department of Veterinary and Comparative Anatomy, College of Veterinary Medicine, Washington State University, Pullman 99164.
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MeSH Terms
Descriptor/Qualifier:
Abnormalities, Drug-Induced / etiology*
Animals
Birth Weight / drug effects
Cocaine* / toxicity
Dose-Response Relationship, Drug
Female
Fetal Diseases / chemically induced*
Litter Size / drug effects
Mice
Mice, Inbred DBA
Models, Biological
Pregnancy
Prenatal Exposure Delayed Effects*
Substance-Related Disorders / complications*
Grant Support
ID/Acronym/Agency:
ES04326/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
50-36-2/Cocaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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