| Preliminary evaluation of image reconstruction by ordered-subset expectation maximization in thallium-201 lung scintigraphy. | |
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MedLine Citation:
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PMID: 14651366 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: We observed whether clearer tumor delineation and greater tumor to non-tumor (T/N) count ratios could be obtained using an iterative ordered-subsets expectation maximization (OSEM) algorithm than conventional filtered-back projection algorithm (FBP) in the image reconstruction of thallium-201 (201Tl) lung scintigraphy. METHODS: In 29 patients with lung cancer and phantom studies, tomograms were reconstructed using FBP and OSEM algorithms, with and without a prefilter (Butterworth filter: BW), whose cut-off frequencies were 0.10 cycles/pixel for FBP and 0.10 and 0.17 cycles/pixel for OSEM. Visual interpretation and tumor to non-tumor (T/N) count ratios were obtained and compared. RESULTS: Without a prefilter, T/N ratios from OSEM and FBP were 1.89 +/- 0.31 (early) and 2.00 +/- 0.54 (late) for OSEM, 1.90 +/- 0.33 (early) and 2.05 +/- 0.59 (late) for FBP, respectively. The OSEM reconstruction without prefiltering showed clearer tumor contours than FBP without a prefilter. Incorporation of BW showed visually low-noised images but decreased T/N ratios in both reconstructions with BW (0.10 cycles/pixel). No greater T/N ratios were obtained by OSEM than FBP, with or without prefiltering. With BW with a cut-off frequency of 0.17 cycles/pixel, the same T/N ratios as those without BW were obtained. The tumor model sized 0.9 cm in the phantom study was invisible in both OSEM and FBP reconstructions without a prefilter, but visible with a prefilter. The influence of prefiltering on T/N ratios was also observed in phantom studies. CONCLUSIONS: Visually improved tumor delineation could be obtained in OSEM reconstruction without a prefilter as compared to FBP reconstruction without a prefilter for tumors greater than 2 cm. Prefiltering should be incorporated into OSEM reconstruction in diagnosing small tumors. However, the influence of prefilter (BW) setting on semi-quantitative interpretation needs further discussion. |
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Authors:
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Jingming Bai; Kunihiko Yokoyama; Seigo Kinuya; Kenichi Nakajima; Masato Yamada; Kenji Ichiyanagi; Takatoshi Michigishi; Norihisa Tonami |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Validation Studies |
Journal Detail:
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Title: Annals of nuclear medicine Volume: 17 ISSN: 0914-7187 ISO Abbreviation: Ann Nucl Med Publication Date: 2003 Oct |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-07-16 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 8913398 Medline TA: Ann Nucl Med Country: Japan |
Other Details:
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Languages: eng Pagination: 619-24 Citation Subset: IM |
Affiliation:
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Department of Biotracer Medicine, Graduate School of Medical Sciences, Kanazawa University, Japan. bjingming@nmd.m.kanazawa-u.ac.jp |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Algorithms* Feasibility Studies Female Humans Image Enhancement / methods* Image Interpretation, Computer-Assisted / methods* Lung Neoplasms / pathology, radionuclide imaging Male Middle Aged Neoplasm Staging / methods Pilot Projects Radiopharmaceuticals / diagnostic use Reproducibility of Results Sensitivity and Specificity Solitary Pulmonary Nodule / pathology, radionuclide imaging* Thallium / diagnostic use* Tomography, Emission-Computed, Single-Photon / methods* |
| Chemical | |
Reg. No./Substance:
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0/Radiopharmaceuticals; 7440-28-0/Thallium; 7791-12-0/thallium chloride |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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