Document Detail


Preliminary evaluation of Leucaena leucocephala seed gum as a tablet binder.
MedLine Citation:
PMID:  9876627     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The seed galactomannan of Leucaena leucocephala Lam. de Wit var.K-8 (family Leguminosae), a natural polysaccharide, with properties comparable to guar gum, was evaluated as a pharmaceutical binder. Characterization was done using studies of compressibility, micromeritic, and mechanical properties of granules prepared by wet granulation and subsequent studies on compacts, both containing 5% w/w of binder. The seed gum was subsequently used as a binder with a badly compressible material, paracetamol, and studied likewise. The seed gum compared will with standard pharmaceutical binders (starch and polyvinyl pyrrolidone [PVP] K30), at least for properties studied herein.
Authors:
U P Deodhar; A R Paradkar; A P Purohit
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Drug development and industrial pharmacy     Volume:  24     ISSN:  0363-9045     ISO Abbreviation:  Drug Dev Ind Pharm     Publication Date:  1998 Jun 
Date Detail:
Created Date:  1999-02-01     Completed Date:  1999-02-01     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7802620     Medline TA:  Drug Dev Ind Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  577-82     Citation Subset:  IM    
Affiliation:
Department of Pharmacognosy, Poona College of Pharmacy, Pune, India.
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MeSH Terms
Descriptor/Qualifier:
Chemistry, Pharmaceutical
Chemistry, Physical
Evaluation Studies as Topic
Excipients*
Fabaceae
Humans
Mannans* / chemistry,  isolation & purification
Physicochemical Phenomena
Plants, Medicinal
Povidone
Starch
Tablets*
Chemical
Reg. No./Substance:
0/Excipients; 0/Mannans; 0/Tablets; 11078-30-1/galactomannan; 9003-39-8/Povidone; 9005-25-8/Starch

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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