Document Detail


Preliminary communication: urodynamic assessment of donepezil hydrochloride in patients with Alzheimer's disease.
MedLine Citation:
PMID:  15605367     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND AND AIMS: Donepezil hydrochloride, a central cholinergic drug, is widely used for improving cognitive decline in Alzheimer's disease (AD). We investigated whether donepezil might affect the lower urinary tract (LUT) function in AD. METHODS: Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) (0-70, increase as impairment), urinary questionnaire, and electromyography (EMG)-cystometry were performed in eight patients with AD before and after treatment with 5 mg/day of donepezil. RESULTS: The first assessment (before donepezil) showed moderate cognitive decline in the patients as a mean ADAS-cog score of 27.0 (range: 17-35) (normal < 15). Seven patients had urinary symptoms including urinary urgency incontinence in five. EMG-cystometry revealed neurogenic detrusor overactivity in seven with a mean detrusor pressure of 44.9 cm H(2)O (20-101), mean bladder capacity of 202 ml (20-412), and post-void residuals in none. The second assessment (3 months after donepezil) showed a decrease in the ADAS-cog score to 23.3 (11-35) though without statistical significance. Urinary incontinence disappeared in one and none had a new onset of incontinence. EMG-cystometry revealed an increase in the detrusor pressure on overactivity to 54.1 cm H(2)O (20-122), but also an increase in the bladder capacity to 234 ml (80-400), and post-void residuals in one (40 ml). CONCLUSION: Although the number of our patients was small, it seems possibly that donepezil could ameliorate cognitive function without serious adverse effects on the LUT function in patients with AD.
Authors:
Ryuji Sakakibara; Tomoyuki Uchiyama; Mitsuharu Yoshiyama; Tomoyuki Yamanishi; Takamichi Hattori
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Neurourology and urodynamics     Volume:  24     ISSN:  0733-2467     ISO Abbreviation:  Neurourol. Urodyn.     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-06-17     Revised Date:  2006-07-17    
Medline Journal Info:
Nlm Unique ID:  8303326     Medline TA:  Neurourol Urodyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-5     Citation Subset:  IM    
Affiliation:
Department of Neurology, Chiba University, Chiba, Japan. sakakibara@faculty.chiba-u.jp
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Alzheimer Disease / complications,  drug therapy*
Electromyography
Female
Humans
Indans / administration & dosage*
Male
Muscle Hypertonia / diagnosis,  drug therapy,  etiology
Nootropic Agents / administration & dosage*
Pilot Projects
Piperidines / administration & dosage*
Treatment Outcome
Urinary Incontinence / diagnosis,  drug therapy*,  etiology
Urodynamics / drug effects*
Chemical
Reg. No./Substance:
0/Indans; 0/Nootropic Agents; 0/Piperidines; 120011-70-3/donepezil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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