Document Detail

Preliminary communication: urodynamic assessment of donepezil hydrochloride in patients with Alzheimer's disease.
MedLine Citation:
PMID:  15605367     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND AIMS: Donepezil hydrochloride, a central cholinergic drug, is widely used for improving cognitive decline in Alzheimer's disease (AD). We investigated whether donepezil might affect the lower urinary tract (LUT) function in AD. METHODS: Alzheimer's Disease Assessment Scale cognitive subscale (ADAS-cog) (0-70, increase as impairment), urinary questionnaire, and electromyography (EMG)-cystometry were performed in eight patients with AD before and after treatment with 5 mg/day of donepezil. RESULTS: The first assessment (before donepezil) showed moderate cognitive decline in the patients as a mean ADAS-cog score of 27.0 (range: 17-35) (normal < 15). Seven patients had urinary symptoms including urinary urgency incontinence in five. EMG-cystometry revealed neurogenic detrusor overactivity in seven with a mean detrusor pressure of 44.9 cm H(2)O (20-101), mean bladder capacity of 202 ml (20-412), and post-void residuals in none. The second assessment (3 months after donepezil) showed a decrease in the ADAS-cog score to 23.3 (11-35) though without statistical significance. Urinary incontinence disappeared in one and none had a new onset of incontinence. EMG-cystometry revealed an increase in the detrusor pressure on overactivity to 54.1 cm H(2)O (20-122), but also an increase in the bladder capacity to 234 ml (80-400), and post-void residuals in one (40 ml). CONCLUSION: Although the number of our patients was small, it seems possibly that donepezil could ameliorate cognitive function without serious adverse effects on the LUT function in patients with AD.
Ryuji Sakakibara; Tomoyuki Uchiyama; Mitsuharu Yoshiyama; Tomoyuki Yamanishi; Takamichi Hattori
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Neurourology and urodynamics     Volume:  24     ISSN:  0733-2467     ISO Abbreviation:  Neurourol. Urodyn.     Publication Date:  2005  
Date Detail:
Created Date:  2005-05-02     Completed Date:  2005-06-17     Revised Date:  2006-07-17    
Medline Journal Info:
Nlm Unique ID:  8303326     Medline TA:  Neurourol Urodyn     Country:  United States    
Other Details:
Languages:  eng     Pagination:  273-5     Citation Subset:  IM    
Department of Neurology, Chiba University, Chiba, Japan.
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MeSH Terms
Aged, 80 and over
Alzheimer Disease / complications,  drug therapy*
Indans / administration & dosage*
Muscle Hypertonia / diagnosis,  drug therapy,  etiology
Nootropic Agents / administration & dosage*
Pilot Projects
Piperidines / administration & dosage*
Treatment Outcome
Urinary Incontinence / diagnosis,  drug therapy*,  etiology
Urodynamics / drug effects*
Reg. No./Substance:
0/Indans; 0/Nootropic Agents; 0/Piperidines; 120011-70-3/donepezil

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