| Preliminary study of the effects of smectite granules (WoundStat) on vascular repair and wound healing in a swine survival model. | |
| | |
MedLine Citation:
|
PMID: 20068476 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: WoundStat (WS) (TraumaCure, Bethesda, MD) is a topical hemostatic agent that effectively stops severe hemorrhage in animal models. To the best of our knowledge, no survival study has been conducted to ensure long-term product safety. We evaluated vascular patency and tissue responses to WS in a swine femoral artery injury model with survival up to 5 weeks. METHODS: Anesthetized swine received a standardized femoral artery injury with free hemorrhage for 45 seconds followed by WS application. One hour after application, the WS was removed, the wound copiously irrigated, and the artery repaired using a vein patch. Six groups of three animals received WS and were killed either immediately after surgery or at weekly intervals up to 5 weeks. Three control animals were treated with gauze packing and direct pressure followed by identical vascular repair and survival for 1 week. At the time of killing, angiograms were performed, and tissue was collected for histopathology. RESULTS: Hemostasis was complete in all WS animals. All animals survived the procedure, and there were no clinically evident postoperative complications. Vascular repairs were angiographically patent in 15 of 18 animals (83%) receiving WS. Histopathologic examination of WS animals revealed severe diffuse fibrogranulomatous inflammation, early endothelial degeneration with subsequent intimal hyperplasia, moderate myocyte necrosis, and fibrogranulomatous nerve entrapment with axonal degeneration. CONCLUSION: Although an effective hemostatic agent, WS use was associated with a substantial local inflammatory response and neurovascular changes up to 5 weeks postinjury. |
| | |
Authors:
|
Travis Gerlach; J Kevin Grayson; Kullada O Pichakron; Matthew J Sena; Steven D DeMartini; Beth Z Clark; J Scot Estep; Dustin Zierold |
Related Documents
:
|
17168286 - Peroneal artery pseudo-aneurysm following blunt injury. 2658706 - Vascular injury about the knee. improved outcome. 1420086 - Time course and cellular characteristics of the iliac artery response to acute balloon ... 20327556 - The diagnosis and treatment of arterial injuries. 16290226 - Dynamic left ventricular outflow tract obstruction secondary to catecholamine excess in... 11581516 - False aneurysm and mediastinal hematoma: complications of simultaneous transcatheter th... |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: The Journal of trauma Volume: 69 ISSN: 1529-8809 ISO Abbreviation: J Trauma Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-11 Completed Date: 2011-01-11 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0376373 Medline TA: J Trauma Country: United States |
Other Details:
|
Languages: eng Pagination: 1203-9 Citation Subset: AIM; IM |
Affiliation:
|
Division of Trauma and Emergency Surgery, Department of Surgery, UC Davis Medical Center, Sacramento, California 95817, USA. travis.gerlach@ucdmc.ucdavis.edu |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Administration, Topical Animals Disease Models, Animal Female Femoral Artery / injuries*, surgery Hemorrhage / etiology, mortality, therapy* Male Silicates / administration & dosage* Survival Rate Swine Vascular Surgical Procedures* Wound Healing / drug effects* Wounds and Injuries / complications, mortality, therapy* |
| Chemical | |
Reg. No./Substance:
|
0/Silicates; 12199-37-0/Smectite |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Refining the Diagnosis and EGFR Status of Non-small Cell Lung Carcinoma in Biopsy and Cytologic Mate...
Next Document: Predictors of Outcome in Penetrating Cardiac Injuries.