| Preliminary Results of an ICP-Controlled Subarachnoid Hemorrhage Rabbit Model for the Study of Delayed Cerebral Vasospasm. | |
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MedLine Citation:
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PMID: 21116933 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Introduction: Intracisternal blood injection is the most common applied experimental subarachoid bleeding technique in rabbits. The model comprises examiner-dependent variables and does not closely represent the human pathophysiological sequelae of ruptured cerebral aneurysm. The degree of achieved delayed cerebral vasospasm (DCVS) in this model is often mild. The aim of this study was to characterize and evaluate the feasibility of a clinically more relevant experimental SAH in vivo model. SAH was performed by arterial blood shunting from the subclavian artery into the great cerebral cistern. A total of five experiments were performed. Intracranial pressure (ICP), arterial blood pressure, heart rate, arterial blood gas analysis, and neurological status were monitored throughout the experiments. SAH induced vasoconstriction of the basilar artery was 52.1±3.4% on day 3 compared to baseline (P<0.05). Post-mortem gross examination of the brain showed massive blood clot accumulation around the brainstem and ventral surface of the brain. The novel technique offers an examiner independent SAH induction and triggers high degrees of delayed cerebral vasospasm. The severity of vasospasm attained offers a unique opportunity to evaluate future therapeutic treatment options. |
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Authors:
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Serge Marbacher; Camillo Sherif; Volker Neuschmelting; Janine-Ai Schläppi; Jukka Takala; Stephan Jakob; Javier Fandino |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta neurochirurgica. Supplement Volume: 110 ISSN: 0065-1419 ISO Abbreviation: Acta Neurochir. Suppl. Publication Date: 2011 |
Date Detail:
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Created Date: 2010-11-30 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100962752 Medline TA: Acta Neurochir Suppl Country: Austria |
Other Details:
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Languages: eng Pagination: 163-5 Citation Subset: IM |
Affiliation:
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Department of Intensive Care Medicine, Bern University Hospital and University of Bern, Bern, Switzerland, serge.marbacher@ksa.ch. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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