| Preliminary results for characterization of pelvic lymph nodes in patients with prostate cancer by diffusion-weighted MR-imaging. | |
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MedLine Citation:
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PMID: 19996762 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: In this retrospective feasibility study diffusion-weighted magnetic resonance imaging (DWI) was evaluated as a potential tool for characterization of pelvic lymph nodes in patients with prostate cancer. METHODS AND MATERIALS: Twenty-nine patients with prostate cancer underwent DWI of the pelvis at 1.5T by a non breath-hold SSEPI sequence using a body phased array coil with b values of 50, 300, and 600 s/mm(2) and an additional T2-weighted sequence. A total of 118 lymph nodes (>6 mm short axis) were analyzed by measuring the ADC-value with a polygon region of interest. Feasibility for ADC-measurement was assessed by comparing the ADC-value from the automatically created ADC-map (ADC(MR_unit)) with a manually calculated ACD-value (ADC(calculated)) and by using a linear-regression model for comparison with size and standard deviation of the ADC-value. Diagnostic performance was estimated by receiver operator characteristic analysis using histologic and/or clinical follow-up as standard of reference. RESULTS: ADC(MR_unit) and ADC(calculated) showed a high correlation (r = 0.8999) with a mean percentual deviation of 6.33%. There was a highly significant difference between the mean ADC-value (x10(-3) mm(2)/s) of malignant (1.07 +/- 0.23) versus benign (1.54 +/- 0.25) lymph nodes, even in subgroup analysis for lymph nodes smaller versus larger than 10 mm. Receiver operator characteristic-analysis showed a good accuracy of the ADC-value (85.6% [101/118]; sensitivity: 86.0% [43/50]; specificity: 85.3% [53/68]) for differentiation of malignant and benign lymph nodes at a cutoff 1.30 x 10(-3) mm(2)/s. This was superior to a size-based analysis at a cutoff of 8 mm (accuracy: 66.1% [78/118]; sensitivity: 82.0% [41/50]; specificity: 54.4% [37/68]; P < 0.01). CONCLUSIONS: DWI has the potential of being an accurate technique for analysis of pelvic lymph nodes. Moreover, our preliminary results suggest that the ADC-value might perform significantly superior to size criteria to discriminate between benign and malignant lymph nodes. |
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Authors:
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Matthias Eiber; Ambros J Beer; Konstantin Holzapfel; Robert Tauber; Carl Ganter; Gregor Weirich; Bernd J Krause; Ernst J Rummeny; Jochen Gaa |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Investigative radiology Volume: 45 ISSN: 1536-0210 ISO Abbreviation: Invest Radiol Publication Date: 2010 Jan |
Date Detail:
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Created Date: 2009-12-22 Completed Date: 2010-03-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0045377 Medline TA: Invest Radiol Country: United States |
Other Details:
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Languages: eng Pagination: 15-23 Citation Subset: IM |
Affiliation:
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Department of Radiology, Technische Universit?t M?nchen, Munich, Germany. matthias.eiber@roe.med.tum.de |
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Aged, 80 and over Diffusion Magnetic Resonance Imaging / methods* Feasibility Studies Follow-Up Studies Humans Lymph Nodes / pathology* Lymphatic Metastasis / diagnosis* Male Middle Aged Prostatic Neoplasms / radiography* Retrospective Studies |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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