| Preliminary report: vitamin D deficiency in advanced cancer patients with symptoms of fatigue or anorexia. | |
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MedLine Citation:
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PMID: 21964001 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Vitamin D deficiency in noncancer patients is associated with symptoms of fatigue, muscle weakness, and depression. These symptoms are common among advanced cancer patients. We investigated the prevalence of low serum vitamin D levels in cancer patients with fatigue or poor appetite and their association with symptom burden and other correctable endocrine abnormalities. METHODS: This was a retrospective review of 100 consecutive cancer patients with appetite or fatigue scores of ≥4 of 10 referred to a supportive care clinic. We investigated serum levels of 25(OH) vitamin D, cortisol, thyroid-stimulating hormone, and bioavailable testosterone. Symptoms were measured by the Edmonton Symptom Assessment Scale. Serum 25(OH) vitamin D <20 ng/mL was considered deficient; ≥20 ng/mL and <30 ng/mL were considered insufficient. RESULTS: Patients were predominantly male (68%) and white (66%), with a median age of 60 years (range, 27-91 years). Gastrointestinal (30%) and lung (22%) cancers were predominant. Forty-seven patients (47%) were vitamin D deficient and 70 (70%) were insufficient. Thirteen of 70 patients (19%) with vitamin D insufficiency were on supplementation. Vitamin D deficiency was more common among nonwhites (82% versus 36%) and females. No significant association was found between vitamin D and symptoms. Hypogonadic males had a significantly lower mean 25(OH) vitamin D level than eugonadic males. CONCLUSIONS: Low vitamin D levels were highly prevalent among advanced cancer patients with cachexia or fatigue. Vitamin D deficiency was more frequent among nonwhite and female patients. Vitamin D levels were also significantly lower in male patients with hypogonadism. |
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Authors:
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Rony Dev; Egidio Del Fabbro; Gary G Schwartz; David Hui; Shana L Palla; Noah Gutierrez; Eduardo Bruera |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2011-09-30 |
Journal Detail:
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Title: The oncologist Volume: 16 ISSN: 1549-490X ISO Abbreviation: Oncologist Publication Date: 2011 |
Date Detail:
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Created Date: 2011-11-30 Completed Date: 2012-06-13 Revised Date: 2013-05-23 |
Medline Journal Info:
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Nlm Unique ID: 9607837 Medline TA: Oncologist Country: United States |
Other Details:
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Languages: eng Pagination: 1637-41 Citation Subset: IM |
Affiliation:
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Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA. rdev@mdanderson.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Anorexia / blood*, etiology Fatigue / blood*, etiology Female Humans Hydrocortisone / blood, metabolism Male Middle Aged Neoplasms / blood*, complications Retrospective Studies Testosterone / blood, metabolism Thyrotropin / blood, metabolism Vitamin D / blood*, metabolism Vitamin D Deficiency / blood* Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01CA1222292.01/CA/NCI NIH HHS; R01CA124481-01/CA/NCI NIH HHS; R01NR010162-01A1/NR/NINR NIH HHS |
| Chemical | |
Reg. No./Substance:
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1406-16-2/Vitamin D; 50-23-7/Hydrocortisone; 58-22-0/Testosterone; 9002-71-5/Thyrotropin |
| Comments/Corrections | |
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