Document Detail

Preliminary report: vitamin D deficiency in advanced cancer patients with symptoms of fatigue or anorexia.
MedLine Citation:
PMID:  21964001     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Vitamin D deficiency in noncancer patients is associated with symptoms of fatigue, muscle weakness, and depression. These symptoms are common among advanced cancer patients. We investigated the prevalence of low serum vitamin D levels in cancer patients with fatigue or poor appetite and their association with symptom burden and other correctable endocrine abnormalities.
METHODS: This was a retrospective review of 100 consecutive cancer patients with appetite or fatigue scores of ≥4 of 10 referred to a supportive care clinic. We investigated serum levels of 25(OH) vitamin D, cortisol, thyroid-stimulating hormone, and bioavailable testosterone. Symptoms were measured by the Edmonton Symptom Assessment Scale. Serum 25(OH) vitamin D <20 ng/mL was considered deficient; ≥20 ng/mL and <30 ng/mL were considered insufficient.
RESULTS: Patients were predominantly male (68%) and white (66%), with a median age of 60 years (range, 27-91 years). Gastrointestinal (30%) and lung (22%) cancers were predominant. Forty-seven patients (47%) were vitamin D deficient and 70 (70%) were insufficient. Thirteen of 70 patients (19%) with vitamin D insufficiency were on supplementation. Vitamin D deficiency was more common among nonwhites (82% versus 36%) and females. No significant association was found between vitamin D and symptoms. Hypogonadic males had a significantly lower mean 25(OH) vitamin D level than eugonadic males.
CONCLUSIONS: Low vitamin D levels were highly prevalent among advanced cancer patients with cachexia or fatigue. Vitamin D deficiency was more frequent among nonwhite and female patients. Vitamin D levels were also significantly lower in male patients with hypogonadism.
Rony Dev; Egidio Del Fabbro; Gary G Schwartz; David Hui; Shana L Palla; Noah Gutierrez; Eduardo Bruera
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2011-09-30
Journal Detail:
Title:  The oncologist     Volume:  16     ISSN:  1549-490X     ISO Abbreviation:  Oncologist     Publication Date:  2011  
Date Detail:
Created Date:  2011-11-30     Completed Date:  2012-06-13     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9607837     Medline TA:  Oncologist     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1637-41     Citation Subset:  IM    
Department of Palliative Care and Rehabilitation Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA.
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MeSH Terms
Aged, 80 and over
Anorexia / blood*,  etiology
Fatigue / blood*,  etiology
Hydrocortisone / blood,  metabolism
Middle Aged
Neoplasms / blood*,  complications
Retrospective Studies
Testosterone / blood,  metabolism
Thyrotropin / blood,  metabolism
Vitamin D / blood*,  metabolism
Vitamin D Deficiency / blood*
Young Adult
Grant Support
R01CA1222292.01/CA/NCI NIH HHS; R01CA124481-01/CA/NCI NIH HHS; R01NR010162-01A1/NR/NINR NIH HHS
Reg. No./Substance:
1406-16-2/Vitamin D; 50-23-7/Hydrocortisone; 58-22-0/Testosterone; 9002-71-5/Thyrotropin

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