Document Detail


A preliminary report on the toxicity of arecoline on early pregnancy in mice.
MedLine Citation:
PMID:  20940028     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Areca nut (Areca catechu) is chewed by roughly 10% of the world population, including India, Taiwan and parts of China. Lower mean birth-weight and higher neonatal jaundice were reported in the babies of betel chewing pregnant women in 1982. Although areca nut chewing during pregnancy has been associated with lower birth weight and premature delivery, the mechanism of such complications is not entirely understood. A possible contributor, arecoline, a major alkaloid in the areca nut, has been reported to be cytotoxic and genotoxic. To determine the influence of arecoline on reproduction, we study the effects of arecoline on embryos during peri-implantation stages in mice. Mice consuming varying dosages of arecoline were checked for their ability to successfully produce viable embryos. In addition, trophoblast outgrowth from mice blastocysts was evaluated the survival status of the embryos. Our investigation revealed that arecoline decreased the number of implanted embryos in early pregnant mice. In addition, trophoblast outgrowth expansion of blastocysts was also inhibited by arecoline. These observations suggest that arecoline is toxic to mouse embryos as early as peri-implantation. Improved understanding of the effects of arecoline during embryogenesis may help to establish public health policies and to develop potential treatments for such patients.
Authors:
Shao-Tung Liu; Gau-Chyi Young; Yi-Chen Lee; Yung-Fu Chang
Related Documents :
1522198 - Cruciate thinning of the zona pellucida for more successful enhancement of blastocyst h...
12838548 - Morphology of the 45,x embryo: an embryoscopic study.
8866548 - Disturbed development of the preimplantation embryo in the insulin-dependent diabetic b...
21077518 - Effect of the length of time that donated embryos are frozen on pregnancy outcome.
10430388 - Gestational hyperlipidemic pancreatitis without non-gestational hyperlipidemia.
3944808 - Stimulus requirements for pregnancy initiation in the golden hamster (mesocricetus aura...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-10-19
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  49     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2010-12-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  144-8     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Department of Kinesiology, Health and Leisure Studies, National Kaohsiung University, Kaohsiung,Taiwan, Republic of China.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Codonopsis lanceolata extract induces G0/G1 arrest and apoptosis in human colon tumor HT-29 cells--i...
Next Document:  Functional p53 is required for effective execution of telomerase inhibition in BCR-ABL-positive CML ...