Document Detail


Prekallikrein deficiency presenting as recurrent cerebrovascular accident: case report and review of the literature.
MedLine Citation:
PMID:  22953077     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
We report the case of a woman with history of hypertension and hyperlipidemia presenting with recurrent episodes consistent clinically with cerebrovascular accidents (CVA), and MRI changes suggestive of ischemia versus vasculitis as their cause. No anatomical neurological, rheumatic, cardioembolic, or arteriosclerotic etiologies could be determined by extensive workup. Incidentally, the patient was found to have prolonged activated Partial Thromboplastin Time (aPTT) and a normal Prothrombin Time (PT); further testing revealed a prekallikrein deficiency. Since no other cause for the CVAs was established, and other prothrombotic states were ruled out, it is proposed that they are clinical manifestations derived from the prekallikrein deficiency, which in a patient with known cardiovascular risk factors could lead to thrombotic complications such as stroke.
Authors:
Esteban Uribe Bojanini; Arturo Loaiza-Bonilla; Agustin Pimentel
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Publication Detail:
Type:  Journal Article     Date:  2012-08-16
Journal Detail:
Title:  Case reports in hematology     Volume:  2012     ISSN:  2090-6579     ISO Abbreviation:  Case Rep Hematol     Publication Date:  2012  
Date Detail:
Created Date:  2012-09-06     Completed Date:  2012-09-06     Revised Date:  2013-04-15    
Medline Journal Info:
Nlm Unique ID:  101576456     Medline TA:  Case Rep Hematol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  723204     Citation Subset:  -    
Affiliation:
Division of Hematology and Department of Medicine, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, 1475 NW 12th Ave Suite 3300, Miami, FL 33136, USA.
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