| Preischemic hyperglycemia leads to rapidly developing brain damage with no change in capillary patency. | |
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MedLine Citation:
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PMID: 9519261 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present experiments were undertaken to explore whether exaggeration of ischemic brain damage by preischemic hyperglycemia is due to lack of capillary patency in the postischemic period. Normo- and hyperglycemic rats were exposed to 10 min of forebrain ischemia. Histopathological changes were evaluated after 6 and 16-18 h of recovery by light microscopy, and capillary patency was assessed at the same time points by a double-staining technique, depicting perfused and morphologically identifiable capillaries. The results demonstrate that some neuronal damage was detectable after 6 h of recirculation which was aggravated after 16-18 h of recirculation in hyperglycemic rats. In contrast, the degree of capillary patency was similar in normo- and hyperglycemic rats. In both groups the perfusion marker, Evans blue, perfused about 95% of all capillaries when injected 10 s before decapitation. Since preischemic hyperglycemia exaggerates brain damage without cessation of capillary perfusion the primary targets of hyperglycemic brain damage may not be capillaries but neurons or glial cells. |
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Authors:
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P A Li; J Vogel; Q P He; M L Smith; W Kuschinsky; B K Siesjö |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Brain research Volume: 782 ISSN: 0006-8993 ISO Abbreviation: Brain Res. Publication Date: 1998 Jan |
Date Detail:
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Created Date: 1998-05-14 Completed Date: 1998-05-14 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0045503 Medline TA: Brain Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 175-83 Citation Subset: IM |
Affiliation:
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Laboratory for Experimental Brain Research, Wallenberg Neuroscience Center, University of Lund, Sweden. lip@usask.sask.ca |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain Damage, Chronic / etiology*, pathology Brain Ischemia / complications*, pathology Capillaries / pathology, physiology Cerebrovascular Circulation / physiology* Hyperglycemia / complications* Male Rats Rats, Wistar Reperfusion Time Factors Vascular Patency / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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5 R01NS07838/NS/NINDS NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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