| Preimplantation genetic diagnosis with HLA matching-a way to save a child. | |
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MedLine Citation:
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PMID: 22524201 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Preimplantation genetic diagnosis can be used to establish a pregnancy with an embryo that is human leucocyte antigen (HLA) matched to a sibling having a hematological or immunological disease and needing a life-saving bone marrow transplantation. The ethical aspects of this procedure have been discussed intensively. The procedure applies where no unrelated HLA-matching donor is available or when transplantation from a HLA-matching sibling is considered a better solution. It is only offered in a limited number of centers in Europe since this is a challenging procedure. Where both HLA matching and diagnosis of a dominant disease is necessary, only a proportion of the embryos can be used, and the procedure is not always technically feasible. The clinical pregnancy rate per cycle started is much lower than following normal in-vitro fertilisation (IVF) due to a high cycle cancellation rate, but measured per transfer, the success rate is only somewhat lower. |
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Authors:
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Hans Jakob Ingerslev; Johnny Hindkjaer |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-4-24 |
Journal Detail:
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Title: Acta obstetricia et gynecologica Scandinavica Volume: - ISSN: 1600-0412 ISO Abbreviation: - Publication Date: 2012 Apr |
Date Detail:
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Created Date: 2012-4-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370343 Medline TA: Acta Obstet Gynecol Scand Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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© 2012 The Authors AOGS© 2012 Nordic Federation of Societies of Obstetrics and Gynecology. |
Affiliation:
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1Fertility Clinic/Center for Preimplantation Genetic Diagnosis, Aarhus University Hospital, Aarhus, Denmark. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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