Document Detail


Preimplantation genetic diagnosis with HLA matching-a way to save a child.
MedLine Citation:
PMID:  22524201     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Preimplantation genetic diagnosis can be used to establish a pregnancy with an embryo that is human leucocyte antigen (HLA) matched to a sibling having a hematological or immunological disease and needing a life-saving bone marrow transplantation. The ethical aspects of this procedure have been discussed intensively. The procedure applies where no unrelated HLA-matching donor is available or when transplantation from a HLA-matching sibling is considered a better solution. It is only offered in a limited number of centers in Europe since this is a challenging procedure. Where both HLA matching and diagnosis of a dominant disease is necessary, only a proportion of the embryos can be used, and the procedure is not always technically feasible. The clinical pregnancy rate per cycle started is much lower than following normal in-vitro fertilisation (IVF) due to a high cycle cancellation rate, but measured per transfer, the success rate is only somewhat lower.
Authors:
Hans Jakob Ingerslev; Johnny Hindkjaer
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-4-24
Journal Detail:
Title:  Acta obstetricia et gynecologica Scandinavica     Volume:  -     ISSN:  1600-0412     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-4-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370343     Medline TA:  Acta Obstet Gynecol Scand     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Authors AOGS© 2012 Nordic Federation of Societies of Obstetrics and Gynecology.
Affiliation:
1Fertility Clinic/Center for Preimplantation Genetic Diagnosis, Aarhus University Hospital, Aarhus, Denmark.
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