Document Detail

Preimplantation Mouse Embryo Is a Target for Opioid Ligand-Receptor Signaling.
MedLine Citation:
PMID:  24855103     Owner:  NLM     Status:  Publisher    
Synchronization of preimplantation embryo development to blastocysts is one of the prerequisite for normal embryo implantation. While previous studies have ascribed an adverse effect to aberrant opioid signaling on embryo and fetal development, it remained elusive whether the opioid system is operative in early pregnancy events. In the present study, employing multiple pharmacological and genetic approaches, we demonstrated that preimplantation embryos spanning the zygote to blastocyst express the opioid receptor subtypes and the oviduct expresses endogenous opioid precursors dynamically, which suggest that the opioid signaling is functionally operative during preimplantation embryo development. Subsequent analysis further revealed that an aberrantly activated opioid signaling by morphine can remarkably derail the normal preimplantation embryo development via inhibiting intracellular calcium mobilization, while a cotreatment of naloxone with morphine can remarkably reverse the adverse effects of morphine on preimplantation embryo development. Besides shedding light on the pathophysiological significance of opioid system during early embryo development in mice, our findings have potential clinical relevance since an abused use of illicit opiate drugs is frequently associated with retarded fetal development and pregnancy failure in women.
Yongjie Chen; Shuangbo Kong; Xiaofang Tang; Yayuan Fu; Bingyan Wang; Shuang Zhang; Haibin Wang
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-5-22
Journal Detail:
Title:  Biology of reproduction     Volume:  -     ISSN:  1529-7268     ISO Abbreviation:  Biol. Reprod.     Publication Date:  2014 May 
Date Detail:
Created Date:  2014-5-23     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0207224     Medline TA:  Biol Reprod     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright 2014 by The Society for the Study of Reproduction.
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