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Prehospital Ticagrelor in ST-Segment Elevation Myocardial Infarction.
MedLine Citation:
PMID:  25494282     Owner:  NLM     Status:  Publisher    
To the Editor: The negative results of the ATLANTIC (Administration of Ticagrelor in the Cath Lab or in the Ambulance for New ST Elevation Myocardial Infarction to Open the Coronary Artery) trial reported by Montalescot et al. (Sept. 11 issue)(1) are not unexpected, since previous pharmacodynamic studies(2),(3) have shown that several hours are required to achieve effective platelet inhibition in patients with myocardial infarction who receive a standard loading dose of ticagrelor. In the ATLANTIC trial, prehospital administration, as compared with in-hospital use, allowed a median time difference of only 31 minutes between the two loading doses. Thus, the . . .
Rocco A Montone; Stephen P Hoole; Nick E J West
Publication Detail:
Journal Detail:
Title:  The New England journal of medicine     Volume:  371     ISSN:  1533-4406     ISO Abbreviation:  N. Engl. J. Med.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-10     Completed Date:  -     Revised Date:  2014-12-11    
Medline Journal Info:
Nlm Unique ID:  0255562     Medline TA:  N Engl J Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  2337-2339     Citation Subset:  -    
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