Document Detail


Pregnant women with HIV infection can expect healthy survival: three-year follow-up.
MedLine Citation:
PMID:  16940856     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To document postpartum disease-free survival of HIV-infected women taking antiretroviral therapy (ART) during pregnancy. METHODS: Laboratory and clinical data were collected on all HIV-infected pregnant women delivering from 1998 to 2002 and followed up until September 2004 at 6 hospitals in London. Mothers were grouped according to receipt of zidovudine monotherapy (ZDVm), highly active antiretroviral therapy (HAART) given during and continued after pregnancy (cHAART), and short-term HAART given during pregnancy and discontinued on delivery (START). RESULTS: Eight-five women took ZDVm, 155 took cHAART, and 71 took START. The mean follow-up for all mothers was 33 months, with a total of 847 person-years. At the first antenatal clinic (ANC) visit, 72% of women were in Centers for Disease Control and Prevention (CDC) stage A, 85% were treatment naive, and the ZDVm group had a median HIV viral load (VL) 10-fold less than those mothers who started HAART during pregnancy. At last follow-up, 1 patient had died and 6 (1.9%) had progressed to CDC stage C; 62% of all women, including a quarter of the ZDVm group, were receiving HAART for their own health; and 83% of all mothers had a VL <50 HIV RNA copies/mL of plasma regardless of whether they were on treatment or not. CONCLUSIONS: The median-term postpartum prognosis of HIV-infected pregnant women with access to HAART is good. Exposure to short-course ZDVm or START during pregnancy did not jeopardize their response to subsequent therapy.
Authors:
Fabiola Martin; Lesley Navaratne; Wahid Khan; Liat Sarner; Danielle Mercey; Jane Anderson; Heather Noble; Ade Fakoya; David A Hawkins; Annemiek De Ruiter; Graham P Taylor
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes (1999)     Volume:  43     ISSN:  1525-4135     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr.     Publication Date:  2006 Oct 
Date Detail:
Created Date:  2006-09-27     Completed Date:  2006-11-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100892005     Medline TA:  J Acquir Immune Defic Syndr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  186-92     Citation Subset:  IM; X    
Affiliation:
St. Mary's NHS Trust, London, United Kingdom. fabiolaaghakhani@yahoo.co.uk
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MeSH Terms
Descriptor/Qualifier:
Adult
Anti-HIV Agents / adverse effects*,  pharmacology,  therapeutic use
Antiretroviral Therapy, Highly Active
Female
Follow-Up Studies
HIV Infections / drug therapy*,  mortality,  transmission
HIV-1 / drug effects,  isolation & purification
Humans
Medical Audit
Pregnancy
Pregnancy Complications, Infectious / drug therapy*
Pregnancy Outcome
Pregnant Women
Zidovudine / adverse effects*,  therapeutic use
Chemical
Reg. No./Substance:
0/Anti-HIV Agents; 30516-87-1/Zidovudine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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