| Pregnant and pseudopregnant mice produce a low cytotoxic alloantibody response when challenged by fetal but not adult F1 alloantigens. | |
| | |
MedLine Citation:
|
PMID: 4020779 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The tertiary cytotoxic alloantibody response of syngeneically pregnant, pseudopregnant and non-pregnant BALB/c mice immunised with semi-allogeneic lymphocytes from fetal and adult (CBA X BALB/c)F1 donors was investigated by the microcytotoxicity method. The pregnant and pseudopregnant animals showed a significantly lower response to fetal alloantigens compared to that towards adult alloantigens (P less than 0.001). In contrast, control non-pregnant recipients showed no diminution of response to fetal alloantigens. These observations suggest that the hormonal status of pregnancy, even in the absence of a conceptus, permits a low cytotoxicity antibody response when challenged specifically by fetal, but not when challenged by adult, F1 alloantigens. |
| | |
Authors:
|
J Marshall; Y W Loke; J Neate; M H Kaufman |
Related Documents
:
|
11437629 - Pregnancy: success and failure within the th1/th2/th3 paradigm. 16586229 - Prevalence of new maternal alloantibodies after intrauterine transfusion for severe rhe... 3217929 - Hla and red blood group antigens in pregnancy disorders. 310989 - T and b lymphocytes in pregnant women. 22629499 - Calcium and bone disorders in pregnancy. 14651749 - Immunology of term and preterm labor. 2223679 - Idiopathic thrombocytopenic purpura in pregnancy: a randomized trial on the effect of a... 17596299 - Role of ryr3 splice variants in calcium signaling in mouse nonpregnant and pregnant myo... 23600369 - Overexpression of cd39 protects in a mouse model of preeclampsia. |
Publication Detail:
|
Type: Comparative Study; Journal Article |
Journal Detail:
|
Title: Journal of reproductive immunology Volume: 7 ISSN: 0165-0378 ISO Abbreviation: J. Reprod. Immunol. Publication Date: 1985 May |
Date Detail:
|
Created Date: 1985-09-12 Completed Date: 1985-09-12 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 8001906 Medline TA: J Reprod Immunol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 243-8 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Cytotoxicity, Immunologic* Female Fetus / immunology Hybridization, Genetic Isoantibodies / biosynthesis* Isoantigens / immunology* Male Mice Mice, Inbred Strains Pregnancy Pseudopregnancy / immunology* |
| Chemical | |
Reg. No./Substance:
|
0/Isoantibodies; 0/Isoantigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Differential effect of human chorionic gonadotrophin on lymphocyte proliferation induced by mitogens...
Next Document: Immunocytochemical localization of antibody during placental transmission of immunity in rats.