Document Detail

Pregnant mare's serum gonadotropin: V. Indomethacin or cortisone and the reversal of antifertility efficacy of pregnant mare's serum gonadotropin.
MedLine Citation:
PMID:  720059     Owner:  NLM     Status:  MEDLINE    
Pregnant mare's serum gonadotropin (PMSG) of 10 IU on day 5 of pregnancy induced luteal demise and consequently an absolute resorption of fetuses and placentae resulted on day 16 of pregnancy. Simultaneous regimen of PMSG and indomethacin or cortisone was found to be consistently effective in preventing the luteolytic effect of PMSG. The growth of the fetuses, placentae as well as corpora lutea was found to be parallel to controls. Similarly, shortening of the duration of pseudopregnancy to 10--12 days in the bilaterally hysterectomized rat by PMSG and its retaining the normal duration of 18--20 days in the presence of indomethacin tempt us to propose that the PMSG-induced luteolysis is possibly reflected through the release of prostaglandin at the ovarian level.
T Gupta; A Chatterjee
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Contraception     Volume:  17     ISSN:  0010-7824     ISO Abbreviation:  Contraception     Publication Date:  1978 Jun 
Date Detail:
Created Date:  1979-02-23     Completed Date:  1979-02-23     Revised Date:  2013-03-26    
Medline Journal Info:
Nlm Unique ID:  0234361     Medline TA:  Contraception     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  547-52     Citation Subset:  IM    
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MeSH Terms
Corpus Luteum / anatomy & histology,  drug effects
Cortisone / pharmacology*
Fertility / drug effects*
Fetus / drug effects
Gonadotropins / blood*
Gonadotropins, Equine / pharmacology*
Indomethacin / pharmacology*
Organ Size
Placenta / drug effects
Progesterone / deficiency
Prostaglandins / metabolism
Prostaglandins F
Reg. No./Substance:
0/Gonadotropins; 0/Gonadotropins, Equine; 0/Prostaglandins; 0/Prostaglandins F; 53-06-5/Cortisone; 53-86-1/Indomethacin; 57-83-0/Progesterone

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