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Pregnancy with concomitant chorioangioma and placental mesenchymal dysplasia: a rare placental abnormality.
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PMID:  23840989     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Background. Pregnancy with concomitant chorioangioma and placental mesenchymal dysplasia (PMD) coexisting with a normal viable fetus is very rare. The literature was reviewed to explore the incidence and genetic origin of this condition. Case. The case was first identified by prenatal ultrasonography, but the prenatal diagnosis only included chorioangioma. PMD was then confirmed during postnatal evaluation, which included gross and histologic examination of the placenta. The macroscopic and microscopic findings were consistent with concomitant chorioangioma and placental mesenchymal dysplasia during pregnancy. Genetic findings confirmed genetic similarity of the chorioangioma and vesicle-like villi with the fetus. Conclusions. The case represents a rare placental abnormality whose pathogenesis and molecular basis need further research. Detailed histologic and genetic analyses are essential for accurate and differential diagnosis.
Wu Qichang; Wang Wenbo; Zheng Liangkai; Kong Hui; He Xiaoqin; Sun Li; Xu Yasong
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Publication Detail:
Type:  Journal Article     Date:  2013-06-10
Journal Detail:
Title:  Case reports in obstetrics and gynecology     Volume:  2013     ISSN:  2090-6684     ISO Abbreviation:  Case Rep Obstet Gynecol     Publication Date:  2013  
Date Detail:
Created Date:  2013-07-10     Completed Date:  2013-07-10     Revised Date:  2013-12-13    
Medline Journal Info:
Nlm Unique ID:  101576454     Medline TA:  Case Rep Obstet Gynecol     Country:  United States    
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Languages:  eng     Pagination:  591956     Citation Subset:  -    
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Journal Information
Journal ID (nlm-ta): Case Rep Obstet Gynecol
Journal ID (iso-abbrev): Case Rep Obstet Gynecol
Journal ID (publisher-id): CRIM.OBGYN
ISSN: 2090-6684
ISSN: 2090-6692
Publisher: Hindawi Publishing Corporation
Article Information
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Copyright © 2013 Wu Qichang et al.
Received Day: 10 Month: 4 Year: 2013
Accepted Day: 7 Month: 5 Year: 2013
Print publication date: Year: 2013
Electronic publication date: Day: 10 Month: 6 Year: 2013
Volume: 2013E-location ID: 591956
PubMed Id: 23840989
ID: 3691898
DOI: 10.1155/2013/591956

Pregnancy with Concomitant Chorioangioma and Placental Mesenchymal Dysplasia: A Rare Placental Abnormality
Wu QichangI1*
Wang WenboI1
Zheng LiangkaiI1
Kong HuiI1
He XiaoqinI1
Sun LiI1
Xu YasongI1
Prenatal Diagnosis Center of Xiamen's Maternal & Child Health Care Hospital, Xiamen, Fujian 361000, China
Correspondence: *Wu Qichang:
[other] Academic Editors: I. MacKenzie and E. F. C. Murta

1. Introduction

Chorioangioma, a benign vascular tumor arising from chorionic tissue, is the most common tumor of the placenta [1]. Large lesions negatively affect outcome for both the mother and fetus [2]. Placental mesenchymal dysplasia (PMD), an abnormality with a diverse etiology, is becoming more widely recognized [3]. Pregnancy with concomitant chorioangioma and placental mesenchymal dysplasia represents a rare combination of abnormalities. In this report, we present a case in which concomitant chorioangioma and placental mesenchymal dysplasia coexisted with and were genetically identical to a normal viable fetus. We also reviewed the literature exploring the underlying cause of PMD.

2. Case Report

An asymptomatic 30-year-old Chinese primigravida underwent her initial routine ultrasonography examination at 25 weeks of gestation. Sonographic examination confirmed a structurally normal fetus with an estimated gestational age of 25 weeks. The placenta appeared bulky and contained a well-defined 83 × 30 × 56 mm mixed-echogenic mass (Figure 1) and areas of multiple cystic echoes without vascular flow giving the mass a moth-eaten appearance (Figure 2); in particular, a well-circumscribed echogenic mass, measuring 115 × 110 × 112 mm and containing anechoic cystic areas, protruded into the amniotic cavity from the fetal surface near the cord insertion (Figure 3). On color Doppler images, the anechoic areas indicated pulsatile blood flow within the intrauterine masses. The largest amniotic fluid pocket measured 7.5 cm, and amniotic fluid index equaled 23.5 cm. The sonographic appearance of the masses and the presence of polyhydramnios suggested a prenatal diagnosis of placental chorioangioma, but the significance of the multiple cystic echoes in the placenta was neglected. The presumptive diagnosis and potential outcome were discussed with the patient. Because the tumors were large and multiple, we suggested referral to a specialized maternal-fetal medicine department for interventional management that could include serial fetal transfusions and fetoscopic laser coagulation of vessels supplying the tumor. The patient refused this alternative and returned to our hospital at 27+3 weeks of gestation in preterm labor. Ultrasonography examination revealed polyhydramnios, with an increase in the amniotic fluid index to 37.5 cm. She was admitted for tocolysis, but this management was unsuccessful. One day after admission a 740 g female was delivered vaginally with Apgar scores of 5 and 8 at 1 min and 5 min, respectively. The maternal serum β-human chorionic gonadotropin (β-hCG) was 4611 milli-international units/mL at 2 days postpartum and was undetectable at 3 weeks postpartum.

The placenta measured 30 × 25 × 4.5 cm and weighed 1370 g, and the largest tumor measured 11 × 8 × 4.5 cm (Figure 4). The fetal plate showed enlarged varicose chorionic vessels (Figure 4). The maternal plate was filled with diffuse vesicle-like structures (Figure 5). The clinical macroscopic features were similar to partial molar pregnancy, but on histopathologic examination, no trophoblastic proliferation was seen in the placenta (Figure 6). The diagnosis of chorioangioma was confirmed histologically in the masses. The masses were classified as angiomatous (capillary) chorioangioma, which is the most common histologic type (Figure 7). The fetal karyotype was 46,XX. Molecular genetic analysis of the vesicle-like stem villi and the chorioangioma using FISH techniques revealed the same 46,XX karyotype (Figure 8). Expression of p57KIP2 in the villous cytotrophoblast was investigated by immunohistochemical examination with Streptavidin-Peroxidase (SP) (Figure 9). On the basis of these findings, a final diagnosis of pregnancy with concomitant chorioangioma and placental mesenchymal dysplasia was made.

3. Discussion

Pregnancy and a live birth with concomitant chorioangioma and PMD are very rare. To our knowledge, only 3 cases of concomitant chorioangioma and PMD have been reported [4]. The rarity of this condition and the interest in its genetic origin and pregnancy outcome prompted this report and our review of the literature.

Placental mesenchymal dysplasia (PMD) was first described in 1991 by Moscoso et al. [5] and has since then become a more widely recognized vascular anomaly. The hallmarks of PMD are placentomegaly and grape-like vesicles resembling partial molar pregnancy on ultrasonography and gross placental examination [6]. The underlying cause of PMD is currently unknown. Some speculate that PMD is a congenital malformation of the mesoderm. This theory is based on observations of mesenchymal hyperplasia in stem villi along with other placental mesenchymal proliferative disorders including chorioangiomas and chorionic vessel dilatation as well as hemangiomas of the fetus [7]. The theory suggests that the combination of PMD and chorioangioma represents a mixed form of congenital malformation of the mesoderm.

No specific clinical symptomatology is associated with PMD. However, PMD has been associated with fetal growth restriction, stillbirth, and Beckwith-Wiedemann syndrome [7]. Large or multiple chorioangiomas have a particularly dismal prognosis due to their high association with maternal and fetal complications, including polyhydramnios, preterm labor, fetal hemolytic anemia, fetal thrombocytopenia, cardiomegaly, intrauterine growth restriction, placental abruption, preeclampsia, and congenital abnormalities [2]. Our case was complicated by polyhydramnios, preterm labor, and prematurity, consistent with the above-mentioned findings.

PMD should be considered in the differential diagnosis of cystic placenta. Ultrasonographic features of this abnormality closely resemble those of partial hydatidiform mole. The coexistence of a large cystic placenta with a phenotypically well-formed fetus is highly unlikely in molar pregnancy and should increase the possibility of a PMD diagnosis. The 2 entities are distinguished primarily by karyotype analysis. Partial moles are triploid, whereas PMD carries a 46,XX karyotype [3]. In the present case, the neonate as well as the vesicle-like stem villi and the chorioangioma shared the 46,XX karyotype. These findings confirmed those of Chen et al., who reported similar genetic identity among the chorioangioma, vesicle-like villi, and fetus [7]. Partial moles also display trophoblastic proliferation, a feature not seen in PMD. In the present case, no trophoblastic proliferation was noted on microscopic examination of the tumors, thereby establishing the diagnosis of PMD.

A review of the literature indicates that approximately 25% cases of PMD are associated with Beckwith-Wiedemann syndrome (BWS), a condition characterized by macrosomia, exomphalos, macroglossia, omphalocele, internal visceromegaly, placentomegaly, and increased susceptibility to childhood tumors [8]. The pathogeneses of BWS and PMD may be similar, with the strongest evidence pointing toward epigenetic imprinting abnormalities involving genes on chromosome 11p15.5. The genetic alterations found in BWS and implicated in PMD may be part of a spectrum, with gene aberrations found solely in the fetus (BWS), localized to the placenta (PMD), or both (PMD plus BWS) [9]. The most commonly involved genes are CDKNIC (p57KIP2), H19, IGF-II, and KVLQT [6]. There have been no major analyses of the frequency of these molecular alterations in PMD. Immunohistochemical staining for the p57KIP2 protein as a diagnostic marker may prove helpful in distinguishing PMD from molar pregnancy [10]; however, this cannot be confirmed if the underlying 11p15.5 abnormality is confined to the placenta. Further research to detect PMD-specific gene abnormalities associated with BWS, using microarray or microsatellite technology or both, may be helpful.

The molecular basis of the placental changes in PMD remains unclear. The presence of 2 distinct cell lines in the placenta of some patients with PMD suggests androgenetic-biparental mosaicism as an etiology [3]. The androgenetic cell line is believed to arise from endoreduplication of the haploid paternal genome, whereas the biparental cell line arises from the combination of the haploid maternal and the paternal genomes. This could also explain the female predominance of the condition.

Many pathologists are unfamiliar with PMD, which may account for the underdiagnosis and underreporting of this entity. Our case documents the salient features of PMD and the distinguishing features from those disorders mimicking this condition, the most important of which is a partial mole.

In conclusion, pregnancy with concomitant chorioangioma and placental mesenchymal dysplasia is very rare. Our case illustrates the importance of a careful gross and histologic examination of the placenta in making an accurate diagnosis. Our findings confirm those of others and suggest that chorioangioma and PMD have the same pathologic origin. Both are derived from the mesoderm, and in our case, the chorioangioma, vesicle-like villi, and the fetus shared an identical genetic profile. However, the pathogenesis and the molecular basis of PMD need further research.

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2. Sepulveda W,Alcalde JL,Schnapp C,Bravo M. Perinatal outcome after prenatal diagnosis of placental chorioangiomaObstetrics and GynecologyYear: 20031025102810332-s2.0-024271171314672481
3. Surti U,Hill LM,Dunn J,Prosen T,Hoffner L. Twin pregnancy with a chimeric androgenetic and biparental placenta in one twin displaying placental mesenchymal dysplasia phenotypePrenatal DiagnosisYear: 20052511104810562-s2.0-2854445167516231321
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5. Moscoso G,Jauniaux E,Hustin J. Placental vascular anomaly with diffuse mesenchymal stem villuos hyperplasia. A new clinico-pathological entity?Pathology Research and PracticeYear: 19911872-33243282-s2.0-0025729980
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8. Weksberg R,Shen DR,Fei YL,Song QL,Squire J. Disruption of insulin-like growth factor 2 imprinting in Beckwith-Wiedemann syndromeNature GeneticsYear: 1993521431502-s2.0-00274203628252039
9. Starikov R,Goldman R,Dizon DS,Kostadinov S,Carr S. Placental mesenchymal dysplasia presenting as a twin gestation with complete molar pregnancyObstetrics and GynecologyYear: 201111824454492-s2.0-7996107149921768849
10. Castrillon DH,Sun D,Weremowicz S,Fisher RA,Crum CP,Genest DR. Discrimination of complete hydatidiform mole from its mimics by immunohistochemistry of the paternally imprinted gene product p57KIP2The American Journal of Surgical PathologyYear: 20012510122512302-s2.0-003481699311688455

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