| Pregnancy with Friedreich ataxia: a retrospective review of medical risks and psychosocial implications. | |
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MedLine Citation:
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PMID: 20478553 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Friedreich ataxia (FRDA) is an autosomal recessive, neurodegenerative disease. Recent medical advances have improved the average life expectancy, and as such, many female patients are contemplating pregnancy. However, little research exists exploring the medical or psychosocial complications that arise from pregnancy with this disease. STUDY DESIGN: In this study, we retrospectively examined 31 women with FRDA who had 65 pregnancies, resulting in 56 live offspring. RESULTS: FRDA did not appear to increase the risk of spontaneous abortion, preeclampsia, or preterm birth. Despite the sensory and proprioceptive loss that occurs in FRDA, nearly four fifths of births were vaginal. Of babies, 94.4% were discharged home with their mothers. Equal numbers of women reported that pregnancy made their disease symptoms worse, better, or unchanged. CONCLUSION: This study demonstrates that women with FRDA can have uncomplicated pregnancies that do not uniformly complicate disease symptomatology. |
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Authors:
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Lisa S Friedman; Erin K Paulsen; Kimberly A Schadt; Karlla W Brigatti; Deborah A Driscoll; Jennifer M Farmer; David R Lynch |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-05-15 |
Journal Detail:
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Title: American journal of obstetrics and gynecology Volume: 203 ISSN: 1097-6868 ISO Abbreviation: Am. J. Obstet. Gynecol. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-09-06 Completed Date: 2010-09-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370476 Medline TA: Am J Obstet Gynecol Country: United States |
Other Details:
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Languages: eng Pagination: 224.e1-5 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Departments of Neurology and Pediatrics, University of Pennsylvania School of Medicine, and Children's Hospital of Philadelphia, Philadelphia, PA, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Spontaneous
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epidemiology Adult Apgar Score Birth Weight Delivery, Obstetric / statistics & numerical data Female Friedreich Ataxia / epidemiology*, psychology* Humans Infant, Newborn Length of Stay / statistics & numerical data Live Birth / epidemiology Pregnancy Pregnancy Complications / epidemiology*, psychology* Premature Birth / epidemiology Retrospective Studies Term Birth |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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