Document Detail

Pregnancy of unknown location: a consensus statement of nomenclature, definitions, and outcome.
MedLine Citation:
PMID:  20947073     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To improve the interpretation of future studies in women who are initially diagnosed with a pregnancy of unknown location (PUL), we propose a consensus statement with definitions of population, target disease, and final outcome.
DESIGN: A review of literature and a series of collaborative international meetings were used to develop a consensus for definitions and final outcomes of women initially diagnosed with a PUL.
RESULT(S): Global differences were noted in populations studied and in the definitions of outcomes. We propose to define initial ultrasound classification of findings into five categories: definite ectopic pregnancy (EP), probable EP, PUL, probable intrauterine pregnancy (IUP), and definite IUP. Patients with a PUL should be followed and final outcomes should be categorized as visualized EP, visualized IUP, spontaneously resolved PUL, and persisting PUL. Those with the transient condition of a persisting PUL should ultimately be classified as nonvisualized EP, treated persistent PUL, resolved persistent PUL, or histologic IUP. These specific categories can be used to characterize the natural history or location (intrauterine vs. extrauterine) of any early gestation where the initial location is unknown.
CONCLUSION(S): Careful definition of populations and classification of outcomes should optimize objective interpretation of research, allow objective assessment of future reproductive prognosis, and hopefully lead to improved clinical care of women initially identified to have a PUL.
Kurt Barnhart; Norah M van Mello; Tom Bourne; Emma Kirk; Ben Van Calster; Cecilia Bottomley; Karine Chung; George Condous; Steven Goldstein; Petra J Hajenius; Ben Willem Mol; Thomas Molinaro; Katherine L O'Flynn O'Brien; Richard Husicka; Mary Sammel; Dirk Timmerman
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Publication Detail:
Type:  Consensus Development Conference; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2010-10-14
Journal Detail:
Title:  Fertility and sterility     Volume:  95     ISSN:  1556-5653     ISO Abbreviation:  Fertil. Steril.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-22     Completed Date:  2011-04-22     Revised Date:  2014-01-20    
Medline Journal Info:
Nlm Unique ID:  0372772     Medline TA:  Fertil Steril     Country:  United States    
Other Details:
Languages:  eng     Pagination:  857-66     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Pregnancy, Ectopic / mortality*,  ultrasonography*
Risk Factors
Terminology as Topic*
Ultrasonography, Prenatal / standards*
World Health
Grant Support
K24 HD060687/HD/NICHD NIH HHS; K24 HD060687-01A1/HD/NICHD NIH HHS; R01 HD036455-10/HD/NICHD NIH HHS; R01-HD036455/HD/NICHD NIH HHS

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