Document Detail

Pregnancy and tuberculosis: to assess tuberculosis cases in pregnancy in a developing region retrospectively and two case reports.
MedLine Citation:
PMID:  18273625     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: Since TB cases activated by HIV infection during pregnancy are well reported in the literature, we aimed to investigate the aggressiveness of pulmonary TB among pregnant women and to assess the effects of TB on the fetus in Kutahya, an area where HIV positive cases are not seen.
MATERIALS AND METHODS: The medical records between 2000 and 2005 of the Provincial Health Directorate and Dispensary Against Tuberculosis in Kutahya were reviewed and analyzed retrospectively.
RESULTS: Between 2000 and 2005, 667 pulmonary TB cases were examined in the Kutahya region. Of these, 106 occurred in women at reproductive ages between 20 and 44. All were HIV negative cases. In this area, five TB cases were found during pregnancy. There were three cases seen in the first trimester, but pregnancy was ended by curettage. Two women had pulmonary TB and gave birth. Five cases were evaluated as class 1 TB. During and after pregnancy, isoniazid, rifampin, ethambutol, and pyrazinamide (INH + RFP + ETB + PRZ) were used for the treatment. Resistance to anti-TB drugs was not seen during the treatment. Neither congenial nor neonatal TB was seen.
CONCLUSION: Generally, TB is expected to be more aggressive during pregnancy. Since our cases were HIV negative, it can be thought that TB did not progress aggressively. Less aggressiveness and non-resistance to TB treatment in HIV-negative pregnant women compared with HIV-positive women were observed. Therefore, HIV infection results in greater mortality than the triple combination of human immunodeficiency virus, mycobacterium TB, and pregnancy. Besides, the advance of TB in pregnant women was not different from that in non-pregnant women in Kutahya. The fetus and the newborn were not affected. INH, RFP, ETB, and PRZ were used for therapy.
Nadi Keskin; Sema Yilmaz
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Publication Detail:
Type:  Journal Article     Date:  2008-02-14
Journal Detail:
Title:  Archives of gynecology and obstetrics     Volume:  278     ISSN:  0932-0067     ISO Abbreviation:  Arch. Gynecol. Obstet.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-09-08     Completed Date:  2009-02-10     Revised Date:  2011-01-11    
Medline Journal Info:
Nlm Unique ID:  8710213     Medline TA:  Arch Gynecol Obstet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  451-5     Citation Subset:  IM    
Department of Obstetrics and Gynecology, The Hospital of Dumlupinar University, Dumlupinar Universitesi Hastanesi, Tavşanli Yolu 10. km, Kutahya, Turkey.
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MeSH Terms
Antitubercular Agents / therapeutic use
Cohort Studies
Developing Countries*
Infectious Disease Transmission, Vertical / prevention & control,  statistics & numerical data
Pregnancy Complications, Infectious / diagnosis,  epidemiology*,  therapy*
Retrospective Studies
Tuberculosis, Pulmonary / diagnosis,  epidemiology*,  therapy*
Young Adult
Reg. No./Substance:
0/Antitubercular Agents

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