Document Detail

Pregnancy and tuberculosis: influence of treatment on perinatal outcome.
MedLine Citation:
PMID:  9643636     Owner:  NLM     Status:  MEDLINE    
The objective of this article is to evaluate the impact of tuberculosis (TB) on perinatal outcome in a cohort of 25 pregnant women with TB treated at the National Institute of Perinatology (Mexico, City) from March 1990 to September 1995. They were compared with a cohort of normal pregnant women; both cohorts were matched by age, gestational age, and socioeconomic status. For purposes of analysis, patients with TB were further stratified into two groups: one included 9 women who started treatment either before or at the beginning of pregnancy, and the other constituted 16 women who started treatment in either the second or third trimester of gestation. Thirteen women (52%) had pulmonary TB, 7 (28%) had renal infection, and the rest of patients had diverse extrapulmonary localization of the infection. Obstetrical morbidity and neonatal mortality were significantly higher in pregnant women with TB who started treatment late in pregnancy. Perinatal morbidity was similar in pregnant women receiving antituberculous drugs early during pregnancy to that in uninfected women. We conclude that TB represents a risk factor for pregnancy. Early treatment of the disease during gestation reverts its negative impact on perinatal outcome.
R Figueroa-Damian; J L Arredondo-Garcia
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  15     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1998 May 
Date Detail:
Created Date:  1998-08-27     Completed Date:  1998-08-27     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  303-6     Citation Subset:  IM    
Infectious Diseases Department, National Institute of Perinatology, Mexico, City, DF, Mexico.
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MeSH Terms
Antitubercular Agents / administration & dosage,  therapeutic use*
Cohort Studies
Infant Mortality
Infant, Newborn
Matched-Pair Analysis
Obstetric Labor, Premature
Pregnancy Complications, Infectious / drug therapy*
Pregnancy Outcome*
Pregnancy Trimesters
Tuberculosis / drug therapy*
Reg. No./Substance:
0/Antitubercular Agents

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