| Pregnancy-triggered antiphospholipid syndrome in a patient with multiple late miscarriages. | |
| | |
MedLine Citation:
|
PMID: 20823115 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Antiphospholipid syndrome (APS) is a multisystemic disorder of coagulation-causing thrombosis in the arterial and venous system as well as pregnancy-related complications such as miscarriage, stillbirth, preterm delivery and pre-eclampsia. The disease is characterized by the autoimmune production of antibodies against phospholipid, a substance found in the cell membrane. We here report the case of a patient with four second trimester miscarriages, who apart from a heterozygous plasminogen activator-inhibitor-1 mutation, had no risk factors explaining her condition. In the subsequent pregnancy she was therefore put on low-molecular-weight heparin, aspirin and granulocyte colony-stimulating factor. Antiphospholipid antibodies (APL), which had been negative before gestation, increased and remained high throughout pregnancy, thus suggesting a pregnancy-induced or -aggravated APS. The patient was kept on the above-mentioned medication and delivered a healthy male baby by Caesarean section after an otherwise uneventful pregnancy. Thus, in order to diagnose and treat pregnancy-triggered APS in patients with unexplained recurrent miscarriage, screening for APL should also be performed at several time points after conception. |
| | |
Authors:
|
Arnd Honig; Joerg B Engel; Sabine E Segerer; Peter Kranke; Sebastian Häusler; Wolfgang Würfel |
Related Documents
:
|
21450025 - Correlation between the cervical length and the amount of bleeding during cesarean sect... 7114505 - Corticosteroid therapy in case of immunologic infertility--a preliminary report. 3084145 - The demonstration of lupus anticoagulant by an enzyme-linked immunoadsorbent assay. 15608315 - Livedo reticularis and pregnancy morbidity in patients negative for antiphospholipid an... 21450025 - Correlation between the cervical length and the amount of bleeding during cesarean sect... 18577315 - Does pregnancy/paternity intention predict contraception use? a study among us soldiers... |
Publication Detail:
|
Type: Journal Article Date: 2010-09-07 |
Journal Detail:
|
Title: Human reproduction (Oxford, England) Volume: 25 ISSN: 1460-2350 ISO Abbreviation: Hum. Reprod. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-10-18 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8701199 Medline TA: Hum Reprod Country: England |
Other Details:
|
Languages: eng Pagination: 2753-4 Citation Subset: IM |
Affiliation:
|
Department of OB/GYN, University of Wuerzburg, Wuerzburg, Germany. arnd_hoenig@hotmail.com |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The effect of DNA methylation inhibitor 5-Aza-2'-deoxycytidine on human endometrial stromal cells.
Next Document: H-Y antibody titers are increased in unexplained secondary recurrent miscarriage patients and associ...