Document Detail

Pregnancy toxemia in the European ferret (Mustela putorius furo).
MedLine Citation:
PMID:  10480641     Owner:  NLM     Status:  MEDLINE    
BACKGROUND AND OBJECTIVE: Pregnancy toxemia may lead to appreciable mortality among jills and their offspring. The objective of this report was to increase awareness of the disease, its likely cause, and practical prevention and treatment measures. METHODS: Ten cases of pregnancy toxemia were evaluated. Jills were in late gestation (mean, 38 days; range, 34 to 42 days) and had large litters (mean, 11.5 kits; range, 7 to 15 kits). RESULTS: The most common clinical signs of disease were lethargy, inappetence, dehydration, and excess shedding. Hematologic and clinical biochemical abnormalities included anemia (4 of 8 jills tested), hypoproteinemia (5 of 7), azotemia (7 of 7), hypocalcemia (5 of 6), hyperbilirubinemia (3 of 3), and high liver enzyme activities (6 of 6). Two jills were found dead; two jills were euthanized, six received supportive treatment, and cesarean section was performed on five. The three jills that survived tended to have less pronounced azotemia, hypoproteinemia, and liver enzyme activity increases and were not anemic. Hepatic lipidosis was observed grossly in all jills that died and was confirmed by histologic examination in four jills. CONCLUSIONS: Pregnancy toxemia in ferrets resembles metabolic diseases in several other animal species and requires aggressive treatment, including supportive care, nutritional supplementation, and cesarean section. Maintaining adequate nutrition and avoiding stress late in gestation may prevent the disease.
M A Batchelder; J A Bell; S E Erdman; R P Marini; J C Murphy; J G Fox
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Laboratory animal science     Volume:  49     ISSN:  0023-6764     ISO Abbreviation:  Lab. Anim. Sci.     Publication Date:  1999 Aug 
Date Detail:
Created Date:  1999-10-20     Completed Date:  1999-10-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  1266503     Medline TA:  Lab Anim Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  372-9     Citation Subset:  IM    
Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge 02139-4307, USA.
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MeSH Terms
Anemia / veterinary
Bilirubin / urine
Blood Proteins / deficiency
Dehydration / veterinary
Eating Disorders / veterinary
Hypocalcemia / veterinary
Ketones / urine
Lipids / analysis
Liver / chemistry,  enzymology,  pathology
Pre-Eclampsia / diagnosis,  pathology,  veterinary*
Sleep Stages
Uremia / veterinary
Reg. No./Substance:
0/Blood Proteins; 0/Ketones; 0/Lipids; 635-65-4/Bilirubin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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