Document Detail

Pregnancy termination using vaginal misoprostol in women with more than one caesarean section.
MedLine Citation:
PMID:  17896259     Owner:  NLM     Status:  MEDLINE    
We set out to evaluate the safety and efficacy of the proposed misoprostol regimen in women with previous multiple caesarean sections. This was a retrospective cohort study of 21 women with more than one caesarean section who underwent termination of pregnancy (TOP) with 400 mug of vaginal misoprostol followed by 200 mug/6 h (max 800 mug). The complete abortion rate was 12/21 (57.14%) and six (28.57%) women had an incomplete abortion. Three TOPs (14.29%) failed. In the first trimester group, only 3/9 (33.34%) aborted completely, while (9/12) 75% second trimester patients aborted completely. There were no major complications. The proposed regimen is considered safe and reasonably effective in second trimester TOPs in women with previous multiple caesarean sections. In first trimester patients, the possibility of manual vacuum aspiration (MVA) should be discussed during counselling, or a higher dose should be used as the effectiveness is low.
A Daponte; G Nzewenga; K D Dimopoulos; F Guidozzi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology     Volume:  27     ISSN:  0144-3615     ISO Abbreviation:  J Obstet Gynaecol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-09-26     Completed Date:  2008-01-15     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309140     Medline TA:  J Obstet Gynaecol     Country:  England    
Other Details:
Languages:  eng     Pagination:  597-600     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University Hospital of Larissa, Larissa, Greece.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / administration & dosage*
Abortion, Induced / methods*
Administration, Intravaginal
Cesarean Section, Repeat
Cohort Studies
Misoprostol / administration & dosage*
Pregnancy Trimester, First
Pregnancy Trimester, Second
Retrospective Studies
Treatment Outcome
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59122-46-2/Misoprostol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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