Document Detail


Pregnancy suppresses experimental autoimmune encephalomyelitis through immunoregulatory cytokine production.
MedLine Citation:
PMID:  18056357     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Women with multiple sclerosis (MS) often experience a decrease in relapse rate during pregnancy, most notably during the third trimester, with a flare of disease activity 3-6 mo postpartum. Studies in experimental autoimmune encephalomyelitis (EAE), an animal model for MS, have shown that pregnancy delays the onset and decreases the incidence of disease. We investigated the effect of pregnancy and the postpartum period in a remitting-relapsing model of murine EAE. When immunization occurs during pregnancy, mice show a reduction in the incidence of EAE as well as a decrease in clinical severity, while mice immunized during the postpartum period exhibit more severe disease. No differences in lymphocyte proliferation or expression of activation markers were noted when immunization occurred during pregnancy as compared with the nonpregnant controls. Mice immunized during pregnancy produced less TNF-alpha and IL-17, and showed an increased number of IL-10-secreting cells within the CD11b+, CD11c+, CD19+, and CD4+/CD25+ populations. No differences were noted in the production of IFN-gamma, IL-2, IL-4, and IL-5. These results suggest that when an Ag is introduced during pregnancy, an immunoregulatory rather than an immunosuppressive or Th2 environment predominates.
Authors:
Melanie A McClain; NaTosha N Gatson; Nicole D Powell; Tracey L Papenfuss; Ingrid E Gienapp; Fei Song; Todd M Shawler; Aaron Kithcart; Caroline C Whitacre
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of immunology (Baltimore, Md. : 1950)     Volume:  179     ISSN:  0022-1767     ISO Abbreviation:  J. Immunol.     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-12-06     Completed Date:  2008-03-04     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985117R     Medline TA:  J Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8146-52     Citation Subset:  AIM; IM    
Affiliation:
Department of Molecular Virology, Immunology and Medical Genetics, The Ohio State University, Columbus, OH 43210, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cytokines / metabolism*
Encephalomyelitis, Autoimmune, Experimental / immunology*
Female
Mice
Mice, Inbred C57BL
Pregnancy
Pregnancy Complications / immunology*
Up-Regulation
Grant Support
ID/Acronym/Agency:
AI43376/AI/NIAID NIH HHS; T32 AI 55411/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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