| Pregnancy: success and failure within the Th1/Th2/Th3 paradigm. | |
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MedLine Citation:
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PMID: 11437629 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Evidence from studies on murine and human pregnancy points to a strong association between maternal Th2-type immunity and successful pregnancy on the one hand and between Th1-type immune reactivity and pregnancy loss on the other. While there is a paucity of data from human pregnancy indicating that Th1-type immune effectors actually lead to pregnancy, it is difficult to ignore the compelling evidence linking inappropriate Th1-type immunity to pregnancy loss. Th2-type immunity and TGF beta secreted by Th3 cells may play protective roles during pregnancy, hence the nexus between a Th2/Th3 shift and successful pregnancy. This paper examines these associations and discusses possible mechanisms underlying immunologically mediated pregnancy failure. |
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Authors:
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R Raghupathy |
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Publication Detail:
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Type: In Vitro; Journal Article; Review |
Journal Detail:
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Title: Seminars in immunology Volume: 13 ISSN: 1044-5323 ISO Abbreviation: Semin. Immunol. Publication Date: 2001 Aug |
Date Detail:
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Created Date: 2001-07-04 Completed Date: 2001-10-11 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9009458 Medline TA: Semin Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 219-27 Citation Subset: IM |
Copyright Information:
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Copyright 2001 Academic Press. |
Affiliation:
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Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24239, Kuwait 13110. Raj@hsc.kuniv.edu.kw |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Habitual
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immunology Animals Cytokines / metabolism Female Humans Mice Pregnancy / immunology* Pregnancy Maintenance / immunology Th1 Cells / immunology* Th2 Cells / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Cytokines |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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