Document Detail

Pregnancy: success and failure within the Th1/Th2/Th3 paradigm.
MedLine Citation:
PMID:  11437629     Owner:  NLM     Status:  MEDLINE    
Evidence from studies on murine and human pregnancy points to a strong association between maternal Th2-type immunity and successful pregnancy on the one hand and between Th1-type immune reactivity and pregnancy loss on the other. While there is a paucity of data from human pregnancy indicating that Th1-type immune effectors actually lead to pregnancy, it is difficult to ignore the compelling evidence linking inappropriate Th1-type immunity to pregnancy loss. Th2-type immunity and TGF beta secreted by Th3 cells may play protective roles during pregnancy, hence the nexus between a Th2/Th3 shift and successful pregnancy. This paper examines these associations and discusses possible mechanisms underlying immunologically mediated pregnancy failure.
R Raghupathy
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Publication Detail:
Type:  In Vitro; Journal Article; Review    
Journal Detail:
Title:  Seminars in immunology     Volume:  13     ISSN:  1044-5323     ISO Abbreviation:  Semin. Immunol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-04     Completed Date:  2001-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9009458     Medline TA:  Semin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-27     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24239, Kuwait 13110.
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MeSH Terms
Abortion, Habitual / immunology
Cytokines / metabolism
Pregnancy / immunology*
Pregnancy Maintenance / immunology
Th1 Cells / immunology*
Th2 Cells / immunology*
Reg. No./Substance:

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