Document Detail


Pregnancy: success and failure within the Th1/Th2/Th3 paradigm.
MedLine Citation:
PMID:  11437629     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Evidence from studies on murine and human pregnancy points to a strong association between maternal Th2-type immunity and successful pregnancy on the one hand and between Th1-type immune reactivity and pregnancy loss on the other. While there is a paucity of data from human pregnancy indicating that Th1-type immune effectors actually lead to pregnancy, it is difficult to ignore the compelling evidence linking inappropriate Th1-type immunity to pregnancy loss. Th2-type immunity and TGF beta secreted by Th3 cells may play protective roles during pregnancy, hence the nexus between a Th2/Th3 shift and successful pregnancy. This paper examines these associations and discusses possible mechanisms underlying immunologically mediated pregnancy failure.
Authors:
R Raghupathy
Related Documents :
3217929 - Hla and red blood group antigens in pregnancy disorders.
17955769 - Number, maturity and phagocytic activity of neutrophils in the three trimesters of preg...
10463499 - Recovery from lymphocytopenia following extracorporeal circulation: simple indicator to...
17000249 - Anti-d in rh positive pregnancies.
9350639 - Differential secretion of chemokines from peripheral blood in pregnant compared with no...
6395269 - Pregnancy-associated depression of cell-mediated immunity.
16157119 - Chronic villitis in untreated neonatal alloimmune thrombocytopenia: an etiology for sev...
1531949 - Fetal growth in aneuploid conditions.
11911619 - Asthma in pregnancy.
Publication Detail:
Type:  In Vitro; Journal Article; Review    
Journal Detail:
Title:  Seminars in immunology     Volume:  13     ISSN:  1044-5323     ISO Abbreviation:  Semin. Immunol.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-07-04     Completed Date:  2001-10-11     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9009458     Medline TA:  Semin Immunol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-27     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Affiliation:
Department of Microbiology, Faculty of Medicine, Kuwait University, P.O. Box 24239, Kuwait 13110. Raj@hsc.kuniv.edu.kw
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Abortion, Habitual / immunology
Animals
Cytokines / metabolism
Female
Humans
Mice
Pregnancy / immunology*
Pregnancy Maintenance / immunology
Th1 Cells / immunology*
Th2 Cells / immunology*
Chemical
Reg. No./Substance:
0/Cytokines

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Extinguishing maternal immune responses during pregnancy: implications for immunosuppression.
Next Document:  The role of gamma/delta T cells in the feto-maternal relationship.