Document Detail


Pregnancy and stem cell behavior.
MedLine Citation:
PMID:  15886884     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The identification of cancer-initiating epithelial subtypes (i.e. cancer stem cells) is important for gaining a more comprehensive understanding of the process of neoplastic transformation and tumorigenesis. Since reproductive history has a major impact on breast tumorigenesis, it is reasonable to assume that pregnancy and lactation have enduring effects on the cancer susceptibility of multipotent progenitors. Using the Cre-lox technology as a tool to genetically label pregnancy-hormone-responsive cells, we identified a mammary epithelial subtype that is abundant in parous females. These pregnancy-induced mammary epithelial cells (PI-MECs) originate from differentiating cells during the first pregnancy and lactation cycle. They do not undergo apoptosis during postlactational remodeling, and they persist throughout the remainder of a female's life. In this review, we discuss the biological relevance of PI-MECs in multiparous females and their important stem cell-like features, such as self renewal, as well as their ability to produce progeny with diverse cellular fates. Using appropriate animal models, we further demonstrate that PI-MECs are cellular targets for pregnancy-enhanced mammary tumorigenesis.
Authors:
Kay-Uwe Wagner; Gilbert H Smith
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Journal of mammary gland biology and neoplasia     Volume:  10     ISSN:  1083-3021     ISO Abbreviation:  J Mammary Gland Biol Neoplasia     Publication Date:  2005 Jan 
Date Detail:
Created Date:  2005-05-11     Completed Date:  2005-08-17     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9601804     Medline TA:  J Mammary Gland Biol Neoplasia     Country:  United States    
Other Details:
Languages:  eng     Pagination:  25-36     Citation Subset:  IM    
Affiliation:
Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198, USA. kuwagner@unmc.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Breast Neoplasms / metabolism,  pathology*
Cell Transformation, Neoplastic
Epithelial Cells / cytology,  metabolism,  pathology
Female
Humans
Lactation / physiology
Parity / physiology*
Pregnancy
Stem Cells / cytology*,  metabolism,  pathology*
Grant Support
ID/Acronym/Agency:
CA93797/CA/NCI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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