| Pregnancy and stem cell behavior. | |
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MedLine Citation:
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PMID: 15886884 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The identification of cancer-initiating epithelial subtypes (i.e. cancer stem cells) is important for gaining a more comprehensive understanding of the process of neoplastic transformation and tumorigenesis. Since reproductive history has a major impact on breast tumorigenesis, it is reasonable to assume that pregnancy and lactation have enduring effects on the cancer susceptibility of multipotent progenitors. Using the Cre-lox technology as a tool to genetically label pregnancy-hormone-responsive cells, we identified a mammary epithelial subtype that is abundant in parous females. These pregnancy-induced mammary epithelial cells (PI-MECs) originate from differentiating cells during the first pregnancy and lactation cycle. They do not undergo apoptosis during postlactational remodeling, and they persist throughout the remainder of a female's life. In this review, we discuss the biological relevance of PI-MECs in multiparous females and their important stem cell-like features, such as self renewal, as well as their ability to produce progeny with diverse cellular fates. Using appropriate animal models, we further demonstrate that PI-MECs are cellular targets for pregnancy-enhanced mammary tumorigenesis. |
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Authors:
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Kay-Uwe Wagner; Gilbert H Smith |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Journal of mammary gland biology and neoplasia Volume: 10 ISSN: 1083-3021 ISO Abbreviation: J Mammary Gland Biol Neoplasia Publication Date: 2005 Jan |
Date Detail:
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Created Date: 2005-05-11 Completed Date: 2005-08-17 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 9601804 Medline TA: J Mammary Gland Biol Neoplasia Country: United States |
Other Details:
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Languages: eng Pagination: 25-36 Citation Subset: IM |
Affiliation:
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Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Nebraska Medical Center, Omaha, Nebraska 68198, USA. kuwagner@unmc.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Breast Neoplasms / metabolism, pathology* Cell Transformation, Neoplastic Epithelial Cells / cytology, metabolism, pathology Female Humans Lactation / physiology Parity / physiology* Pregnancy Stem Cells / cytology*, metabolism, pathology* |
| Grant Support | |
ID/Acronym/Agency:
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CA93797/CA/NCI NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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