Document Detail

Pregnancy-specific changes of antipyrine pharmacokinetics correlate inversely with changes of estradiol/progesterone plasma concentration ratios.
MedLine Citation:
PMID:  3360969     Owner:  NLM     Status:  MEDLINE    
Antipyrine pharmacokinetics as well as estradiol and progesterone concentrations were measured in plasma of 11 healthy pregnant women during the first two trimesters and again in the same patients 6 to 20 weeks after interruption of pregnancy. During pregnancy, the clearance of antipyrine increased and its half-life decreased in all but two instances. A significant inverse relationship was found between the degree of pregnancy-specific changes of plasma clearance of antipyrine and estradiol-progesterone plasma concentration ratios: high estradiol-progesterone ratios during pregnancy corresponded to decreased plasma clearance of antipyrine; low ratios of the two hormones during pregnancy corresponded to increased plasma clearance of antipyrine. The current results indicate that the balance between circulating estrogens and progesterone may be an appropriate indicator for pregnancy-specific changes of a particular hepatic drug metabolism during pregnancy.
W Loock; H Nau; M Schmidt-Gollwitzer; B H Dvorchik
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of clinical pharmacology     Volume:  28     ISSN:  0091-2700     ISO Abbreviation:  J Clin Pharmacol     Publication Date:  1988 Mar 
Date Detail:
Created Date:  1988-06-09     Completed Date:  1988-06-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0366372     Medline TA:  J Clin Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  216-21     Citation Subset:  IM    
Institute of Toxicology and Embryopharmacology, Free University Berlin, FRG.
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MeSH Terms
Antipyrine / metabolism,  pharmacokinetics*
Estradiol / blood*,  physiology
Pregnancy / blood,  metabolism*
Progesterone / blood*,  physiology
Reg. No./Substance:
50-28-2/Estradiol; 57-83-0/Progesterone; 60-80-0/Antipyrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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