Document Detail

Pregnancy-specific beta 1-glycoprotein-like material in human cerebrospinal fluid.
MedLine Citation:
PMID:  7042739     Owner:  NLM     Status:  MEDLINE    
Human cerebrospinal fluid (CSF) from 34 unselected neurological patients was studied for pregnancy-specific beta 1-glycoprotein (SP1) activity because of the recent finding of SP1 production by cultured glial cells. An organic central nervous system lesion was diagnosed in 9 patients, but not in the other 25. Low levels of SP1 immunoreactivity were found in CSF by RIA, and the adsorption of anti-SP1 antiserum with concentrated CSF abolished the positive immunohistochemical staining of placental tissue obtained with the unadsorbed antiserum. By means of immunoadsorption using monoclonal anti-SP1 antibodies, it was possible to isolate SP1 immunoreactive material from CSF and to demonstrate that it had the same electrophoretic mobility in sodium dodecyl sulfate-polyacrylamide gel electrophoresis as purified placental SP1. These results show that CSF contains SP1-like material that is closely related, if not identical, to placental SP1. The amount of SP1 in CSF has no direct correlation to an organic central nervous system lesion or to abnormality of the CSF.
M Heikinheimo; T Wahlström; V P Lehto; B Bång; M Hurme; J Palo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  55     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  1982 Jul 
Date Detail:
Created Date:  1982-07-22     Completed Date:  1982-07-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  189-92     Citation Subset:  AIM; IM    
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MeSH Terms
Adenocarcinoma / cerebrospinal fluid
Brain Neoplasms / cerebrospinal fluid
Cerebral Infarction / cerebrospinal fluid
Electrophoresis, Polyacrylamide Gel
Immunoenzyme Techniques
Middle Aged
Multiple Sclerosis / cerebrospinal fluid
Pregnancy Proteins / cerebrospinal fluid*
Pregnancy-Specific beta 1-Glycoproteins / cerebrospinal fluid*
Seizures / cerebrospinal fluid
Reg. No./Substance:
0/Pregnancy Proteins; 0/Pregnancy-Specific beta 1-Glycoproteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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