Document Detail

Pregnancy and scleroderma.
MedLine Citation:
PMID:  1285889     Owner:  NLM     Status:  MEDLINE    
Scleroderma is a rare disease with a marked female excess in incidence. The pattern of age of onset, together with the effects of the disease, are such that the majority of women with scleroderma experience pregnancy prior to diagnosis. There are three questions of interest: (1) Does pregnancy adversely affect the prognosis of scleroderma? Isolated case reports suggest that renal disease, and in particular hypertensive crises, are associated with pregnancy in the absence of any renal abnormality before pregnancy. However, such events are rare. (2) Does scleroderma adversely affect either fertility or the outcome of pregnancy? Women with established scleroderma, again in case series, have a high rate of spontaneous miscarriage which is not found consistently in epidemiological studies. Prematurity and low birth rates are more frequent problems. (3) Does reproductive history influence disease and particularly Raynaud's phenomenon may antedate diagnosis by many years and might influence reproductive outcome, in general reproductive outcome is similar to that seen after diagnosis, although fertility appears to be reduced.
A J Silman
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  American journal of reproductive immunology (New York, N.Y. : 1989)     Volume:  28     ISSN:  1046-7408     ISO Abbreviation:  Am. J. Reprod. Immunol.     Publication Date:    1992 Oct-Dec
Date Detail:
Created Date:  1993-03-18     Completed Date:  1993-03-18     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  8912860     Medline TA:  Am J Reprod Immunol     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  238-40     Citation Subset:  IM    
ARC Epidemiology Research Unit, University of Manchester, United Kingdom.
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MeSH Terms
Abortion, Spontaneous / epidemiology,  etiology
Infant, Low Birth Weight
Infant, Newborn
Infertility, Female / epidemiology,  etiology
Pregnancy Complications*
Pregnancy Outcome / epidemiology
Scleroderma, Systemic* / complications

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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