Document Detail

Pregnancy and the risk of hemorrhage from cerebral arteriovenous malformations.
MedLine Citation:
PMID:  2274126     Owner:  NLM     Status:  MEDLINE    
We conducted a retrospective analysis of 451 women with an arteriovenous malformation (AVM) of the brain to determine whether pregnancy is a risk factor for cerebral hemorrhages. A total of 540 pregnancies occurred among our patient population, resulting in 438 live births and 102 abortions. There were 17 pregnancies complicated by a cerebral hemorrhage. The hemorrhage rate during pregnancy for women with an unruptured AVM was 0.035 +/- 0.005 per person-year. The hemorrhage rate for nonpregnant women of childbearing age with an unruptured AVM was 0.031 +/- 0.002 per person-year. Pregnancy did not increase significantly the rate of first cerebral hemorrhage from an AVM (P = 0.35). We found that women with an AVM face a 3.5% risk of hemorrhage during pregnancy. Pregnancy is not a risk factor for hemorrhage in women without a previous hemorrhage. This conclusion assumes no selection bias exists in our study population; a bias would be introduced if the risk of fatal outcome after a hemorrhage were greater in pregnant women than in nonpregnant women.
J C Horton; W A Chambers; S L Lyons; R D Adams; R N Kjellberg
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurosurgery     Volume:  27     ISSN:  0148-396X     ISO Abbreviation:  Neurosurgery     Publication Date:  1990 Dec 
Date Detail:
Created Date:  1991-02-28     Completed Date:  1991-02-28     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802914     Medline TA:  Neurosurgery     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  867-71; discussion 871-2     Citation Subset:  IM    
Department of Neurology and Neurosurgery, Massachusetts General Hospital, Boston.
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MeSH Terms
Cerebral Hemorrhage / epidemiology,  etiology*
Intracranial Arteriovenous Malformations / complications*
Pregnancy Complications, Cardiovascular*
Retrospective Studies
Risk Factors

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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