| Pregnancy risk factors for very premature delivery: what role do hypertension, obesity and diabetes play? | |
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MedLine Citation:
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PMID: 23400353 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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PURPOSE: Very premature delivery is a major cause of infant morbidity and mortality. Obesity, diabetes and pregnancy hypertension are known risk factors for pregnancy complications. The study aimed to scrutinize differences of pregnancy complications in a cohort of very premature deliveries compared to a national group. METHODS: In a multicenter study performed between January 2009 and December 2010 including 1,577 very low birth weight (VLBW) infants, we compared parental reported pregnancy problems of VLBW infants with a national cohort (KIGGS). We compared reported pregnancy complications to reasons for premature delivery and neonatal outcome within the group of VLBW infants. RESULTS: While parents of the national cohort reported pregnancy-induced hypertension in 8 %, parents of VLBW infants reported this complication more frequently (27 %). Mothers of the national cohort were significantly younger (1 year), suffered less from obesity, anaemia, diabetes. Regression analysis showed that hypertension (OR = 5.11) and advanced maternal age (OR = 1.03) increased the risk for premature birth. Women with hypertension were likely to experience a clinically indicated premature delivery, had more VLBW infants with a moderate growth restriction, but less multiples and their infants had less intraventricular haemorrhages grade 3 or 4. Otherwise, neonatal outcome was correlated with gestational age but not with the pregnancy complications diabetes, hypertension or obesity. CONCLUSION: Premature birth seems to be correlated to gestational hypertension and associated problems in about ¼ of VLBW infants. Further studies should focus on preventing and treating gestational hypertension to avoid premature delivery and associated neonatal morbidity. |
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Authors:
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Juliane Spiegler; G Stichtenoth; J Weichert; I R König; M Schlaud; A V D Wense; D Olbertz; H Gurth; J-H Schiffmann; B Bohnhorst; L Gortner; E Herting; W Göpel; |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-2-12 |
Journal Detail:
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Title: Archives of gynecology and obstetrics Volume: - ISSN: 1432-0711 ISO Abbreviation: Arch. Gynecol. Obstet. Publication Date: 2013 Feb |
Date Detail:
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Created Date: 2013-2-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8710213 Medline TA: Arch Gynecol Obstet Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Pediatrics, University of Lübeck, Ratzeburger Allee 160, 23538, Lüebeck, Germany, uni@dr-spiegler.de. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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