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Pregnancy and risk of acute myeloid leukaemia - a case-control study.
MedLine Citation:
PMID:  21557774     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Although maternal haematopoiesis is characterised by rapid proliferation and immunological adjustment, leukaemia seldom occurs in pregnant women. In this case-control study we investigated pregnancy and risk of acute myeloid leukaemia (AML). 785 women with AML diagnosed in ages 15 to 50, were compared to 1576 age and sex matched controls. 13 cases and 53 controls were pregnant at the time of diagnosis (1.3% and 3.4%, respectively), resulting in a significantly reduced odds ratio of 0.44 (95% confidence interval 0.22-0.85). Odds ratios of AML during the years following childbirth were close to unity. The results suggest that pregnancy conveys a strong short-term protection against AML.
Authors:
Gunnar Larfors; Martin Höglund; Sven Cnattingius
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-9
Journal Detail:
Title:  European journal of haematology     Volume:  -     ISSN:  1600-0609     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8703985     Medline TA:  Eur J Haematol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2011 John Wiley & Sons A/S.
Affiliation:
Unit of Clinical Epidemiology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden Unit of Haematology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
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