Document Detail


Pregnancy-related exacerbation of iatrogenic keratectasia despite corneal collagen crosslinking.
MedLine Citation:
PMID:  18571094     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Iatrogenic keratectasia after laser in situ keratomileusis (LASIK) represents a serious complication of refractive laser surgery. We describe a woman who developed bilateral iatrogenic keratectasia during her first pregnancy 26 months after LASIK. Corneal collagen crosslinking (CCL) with riboflavin and ultraviolet-A was performed in March 2005 (right eye) and April 2005 (left eye). This treatment stopped the progression and even caused the keratometric steepness to regress over a postoperative follow-up of 22 months, as demonstrated by preoperative and postoperative corneal topographies and maximum K-readings. During the patient's second pregnancy, the keratectasia exacerbated. To our knowledge, this is the first case showing exacerbation of keratectasia despite CCL and, as the exacerbation occurred only during pregnancy, suggesting that hormonal changes might affect corneal biomechanical stability.
Authors:
Farhad Hafezi; Hans Peter Iseli
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Journal of cataract and refractive surgery     Volume:  34     ISSN:  0886-3350     ISO Abbreviation:  J Cataract Refract Surg     Publication Date:  2008 Jul 
Date Detail:
Created Date:  2008-06-23     Completed Date:  2008-07-31     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8604171     Medline TA:  J Cataract Refract Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1219-21     Citation Subset:  IM    
Affiliation:
Institute for Refractive and Ophthalmic Surgery, Zurich, Switzerland. farhad.hafezi@iroc.ch
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MeSH Terms
Descriptor/Qualifier:
Adult
Collagen / metabolism*,  radiation effects
Cornea / metabolism,  pathology*
Corneal Diseases / etiology*
Corneal Topography
Dilatation, Pathologic / etiology
Female
Humans
Iatrogenic Disease*
Keratomileusis, Laser In Situ
Lasers, Excimer / therapeutic use
Photosensitizing Agents / therapeutic use
Pregnancy
Pregnancy Complications*
Riboflavin / therapeutic use
Ultraviolet Rays
Chemical
Reg. No./Substance:
0/Photosensitizing Agents; 83-88-5/Riboflavin; 9007-34-5/Collagen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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