| Pregnancy related effects on Lamivudine Pharmacokinetics: a Population Study with 228 women. | |
| | |
MedLine Citation:
|
PMID: 22106227 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
The aim of this study was to describe lamivudine (3TC) pharmacokinetics (PK) in HIV-infected non pregnant, pregnant women and their fetus. Samples were collected according to a therapeutic drug monitoring in 228 women treated with lamivudine and retrospectively analyzed by a population approach. They were also collected in cord blood and amniotic fluid at birth. Lamivudine pharmacokinetics was ascribed to an open 2- compartment with linear absorption and elimination. Mean population parameter estimates (inter-subject variability) were, for women, absorption rate constant 1.04 h(-1), elimination clearance 23.6 (0.266) L.h(-1) central volume of distribution 109 (0.897) L, intercompartmental clearance 6.7 L/h and peripheral volume of distribution 129 L. A fetal compartment was linked to maternal circulation by mother-to-cord (or fetus) and cord-to-mother rate constants, 0.463 h(-1) and 0.538 h(-1) respectively. The amniotic fluid compartment was connected to the fetal compartment with an elimination rate constant, 0.163 h(-1), and a fixed constant swallowing flow. Placental transfer expressed as fetal-to-maternal AUCs ratio was 0.86 and lamivudine amniotic fluid accumulation expressed as amniotic-fluid-to-fetal AUCs ratio was 2.9. Pregnant women had a 22% higher apparent clearance compared to non pregnant and parturient women, however this increase did not lead to a subexposure and should not require dosage adjustment. |
| | |
Authors:
|
Sihem Benaboud; Jean Marc Tréluyer; Saik Urien; Stéphane Blanche; Naim Bouazza; Hélène Chappuy; Elisabeth Rey; Emmanuelle Pannier; Ghislaine Firtion; Odile Launay; Déborah Hirt |
Related Documents
:
|
1373447 - Elevated maternal serum alpha-fetoprotein levels and maternal risk factors. their assoc... 9196967 - Knowledge about folic acid and the prevention of neural tube defects in two general pra... 1716947 - Serum alpha 1-microglobulin and beta 2-microglobulin for the estimation of fetal glomer... 19089857 - Including prenatal diagnoses in birth defects monitoring: experience of the metropolita... 9127127 - Fetal plasma lipid peroxide levels in pregnancies complicated by preeclampsia. 20549767 - Accuracy of four-dimensional spatiotemporal image correlation echocardiography in the p... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-11-21 |
Journal Detail:
|
Title: Antimicrobial agents and chemotherapy Volume: - ISSN: 1098-6596 ISO Abbreviation: - Publication Date: 2011 Nov |
Date Detail:
|
Created Date: 2011-11-22 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0315061 Medline TA: Antimicrob Agents Chemother Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
Université Paris Descartes, EA3620, Paris, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of Body Weight, Ethnicity, Oral Contraceptives and Pregnancy on the Pharmacokinetics of Az...
Next Document: Potent Antiviral Activity of Topoisomerase I and II Inhibitors Against Kaposi's Sarcoma-associated H...