Document Detail

Pregnancy-related complications in women with reflux nephropathy.
MedLine Citation:
PMID:  8137569     Owner:  NLM     Status:  MEDLINE    
Three hundred and forty-five pregnancies in 137 women with reflux nephropathy have been studied. All pregnancies took place after 1971. Overall foetal loss was 48 (14%) of which only 6 (2%) were therapeutic abortions. Maternal complications (urine infection, hypertension, proteinuria, oedema, deterioration in renal function, hematuria or renal stones) occurred alone or in combination in 39% of pregnancies. Fifty-two pregnancies took place in women with plasma creatinine (P.Cr > 0.11 mmol/l) prior to conception. Foetal loss after 12 weeks gestation (excluding therapeutic abortions) was 18% compared with 8% in the 104 pregnancies where maternal P.Cr was known to be < or = o.11 per/l at conception (p < 0.05). Maternal complications were also more common in the impaired renal function group (p < 0.001). Comparison of pregnancies in women with unilateral versus bilateral renal scarring revealed no significant difference in foetal loss but an increased incidence of over 50% maternal complications in the bilateral renal scar group (p < 0.01). The incidence of pre-eclampsia was higher in women with bilateral renal scars, 50 (24%) than in women with unilateral scars 8 (7%) (p < 0.001). Persistent vesicoureteric reflux was not associated with increased foetal loss or maternal risk. Impaired renal function prior to conception is associated with increased foetal and maternal complications in pregnancy. Bilateral renal scarring is associated with increased maternal complications during pregnancy.
M el-Khatib; D K Packham; G J Becker; P Kincaid-Smith
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Clinical nephrology     Volume:  41     ISSN:  0301-0430     ISO Abbreviation:  Clin. Nephrol.     Publication Date:  1994 Jan 
Date Detail:
Created Date:  1994-04-26     Completed Date:  1994-04-26     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0364441     Medline TA:  Clin Nephrol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  50-5     Citation Subset:  IM    
Department of Nephrology, Royal Melbourne Hospital, Australia.
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MeSH Terms
Abortion, Spontaneous / etiology
Kidney / pathology,  physiopathology
Kidney Diseases / etiology
Pre-Eclampsia / etiology
Pregnancy Complications / etiology*
Pregnancy Outcome
Pyelonephritis / complications*,  pathology
Vesico-Ureteral Reflux / complications*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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