| Pregnancy-related changes in connections from the cervix to forebrain and hypothalamus in mice. | |
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MedLine Citation:
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PMID: 20453158 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The transneuronal tracer pseudorabies virus was used to test the hypothesis that connections from the cervix to the forebrain and hypothalamus are maintained with pregnancy. The virus was injected into the cervix of nonpregnant or pregnant mice, and, after 5 days, virus-labeled cells and fibers were found in specific forebrain regions and, most prominently, in portions of the hypothalamic paraventricular nucleus. With pregnancy, fewer neurons and fibers were evident in most brain regions compared to that in nonpregnant mice. In particular, little or no virus was found in the medial and ventral parvocellular subdivisions, anteroventral periventricular nucleus, or motor cortex in pregnant mice. By contrast, labeling of virus was sustained in the dorsal hypothalamus and suprachiasmatic nucleus in all groups. Based upon image analysis of digitized photomicrographs, the area with label in the rostral and medial parvocellular paraventricular nucleus and magnocellular subdivisions was significantly reduced in mice whose cervix was injected with virus during pregnancy than in nonpregnant mice. The findings indicate that connections from the cervix to brain regions that are involved in sensory input and integrative autonomic functions are reduced during pregnancy. The findings raise the possibility that remaining pathways from the cervix to the forebrain and hypothalamus may be important for control of pituitary neuroendocrine secretion, as well as for effector functions in the cervix as pregnancy nears term. |
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Authors:
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Steven M Yellon; Lauren A Grisham; Genevieve M Rambau; Thomas J Lechuga; Michael A Kirby |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-05-07 |
Journal Detail:
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Title: Reproduction (Cambridge, England) Volume: 140 ISSN: 1741-7899 ISO Abbreviation: Reproduction Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-29 Completed Date: 2010-10-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100966036 Medline TA: Reproduction Country: England |
Other Details:
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Languages: eng Pagination: 155-64 Citation Subset: IM |
Affiliation:
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Departments of Physiology, Center for Perinatal Biology, School of Medicine, Loma Linda University, Loma Linda, California 92354, USA. syellon@llu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cervix Uteri / anatomy & histology, innervation* Female Herpesvirus 1, Suid Image Processing, Computer-Assisted Mice Mice, Inbred C3H Neural Pathways / anatomy & histology, growth & development*, physiology* Neurosecretory Systems / physiology Paraventricular Hypothalamic Nucleus / anatomy & histology, physiology* Pregnancy Pregnancy, Animal / physiology* Prosencephalon / anatomy & histology, physiology* Suprachiasmatic Nucleus / cytology, physiology |
| Grant Support | |
ID/Acronym/Agency:
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HD054931/HD/NICHD NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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