Document Detail

Pregnancy rate in IVF rescue in high responders to human menopausal gonadotropin.
MedLine Citation:
PMID:  10575579     Owner:  NLM     Status:  MEDLINE    
PURPOSE: In vitro fertilization had been previously suggested by us as a means of "rescue" for patients with imminent ovarian hyperstimulation syndrome (OHSS) during treatment with human menopausal gonadotropin (hMG). We evaluated the pregnancy rate of rescued IVF cycles.
METHODS: During the years 1994-1995, women treated with hMG and at risk of developing OHSS were referred to our IVF unit. Their estradiol level was above 1500 pg/ml, and eight or more follicles were observed by ultrasonography in all the patients. These high responders were offered the option to undergo ovum aspiration. We report the pregnancy rate in this group of patients.
RESULTS: Thirty-nine women were referred to our unit for rescue IVF. Two were uneligible due to high progesterone concentrations. Thirty-seven women underwent ovum pickup and 32 had embryo transfer. The clinical pregnancy rate was 40% (13/32). Only two women had clinical OHSS.
CONCLUSIONS: We suggest that rescue IVF may be considered in hMG cycles of high responders with imminent OHSS. Rescue IVF offers a high rate of conception, avoids high-order multiple pregnancy, and appears not to increase the risk of OHSS in these women.
A Many; F Azem; J B Lessing; I Yovel; H Yavetz; A Amit
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of assisted reproduction and genetics     Volume:  16     ISSN:  1058-0468     ISO Abbreviation:  J. Assist. Reprod. Genet.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-15     Completed Date:  1999-12-15     Revised Date:  2013-02-19    
Medline Journal Info:
Nlm Unique ID:  9206495     Medline TA:  J Assist Reprod Genet     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  520-2     Citation Subset:  IM    
Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Israel.
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MeSH Terms
Embryo Transfer
Fertility Agents, Female / adverse effects*,  therapeutic use
Fertilization in Vitro*
Menotropins / adverse effects*,  therapeutic use
Ovarian Hyperstimulation Syndrome / chemically induced,  prevention & control,  ultrasonography
Pregnancy Rate*
Reg. No./Substance:
0/Fertility Agents, Female; 61489-71-2/Menotropins

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