Document Detail


Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis.
MedLine Citation:
PMID:  22406114     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During pregnancy, it is evolutionarily advantageous for inflammatory immune responses that might lead to fetal rejection to be reduced and anti-inflammatory responses that promote transfer of maternal antibodies to the fetus to be increased. Hormones modulate the immunological shift that occurs during pregnancy. Estrogens, including estradiol and estriol, progesterone, and glucocorticoids increase over the course of pregnancy and affect transcriptional signaling of inflammatory immune responses at the maternal-fetal interface and systemically. During pregnancy, the reduced activity of natural killer cells, inflammatory macrophages, and helper T cell type 1 (Th1) cells and production of inflammatory cytokines, combined with the higher activity of regulatory T cells and production of anti-inflammatory cytokines, affects disease pathogenesis. The severity of diseases caused by inflammatory responses (e.g., multiple sclerosis) is reduced and the severity of diseases that are mitigated by inflammatory responses (e.g., influenza and malaria) is increased during pregnancy. For some infectious diseases, elevated inflammatory responses that are necessary to control and clear a pathogen have a negative consequence on the outcome of pregnancy. The bidirectional interactions between hormones and the immune system contribute to both the outcome of pregnancy and female susceptibility to disease.
Authors:
Dionne P Robinson; Sabra L Klein
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-03-03
Journal Detail:
Title:  Hormones and behavior     Volume:  62     ISSN:  1095-6867     ISO Abbreviation:  Horm Behav     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-10-01     Completed Date:  2013-03-14     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  0217764     Medline TA:  Horm Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  263-71     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Inc. All rights reserved.
Affiliation:
The W. Harry Feinstone Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmunity / immunology*
Cytokines / metabolism
Disease Susceptibility
Estradiol / metabolism
Female
Glucocorticoids / metabolism
Humans
Inflammation / immunology*,  metabolism
Pregnancy / immunology*
Pregnancy, Animal / immunology*
Progesterone / metabolism
T-Lymphocytes / immunology*,  metabolism
Grant Support
ID/Acronym/Agency:
AI079342/AI/NIAID NIH HHS; AI089034/AI/NIAID NIH HHS; AI090344/AI/NIAID NIH HHS; R21 AI079342-01A1/AI/NIAID NIH HHS; R21 AI090344-02/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Cytokines; 0/Glucocorticoids; 50-28-2/Estradiol; 57-83-0/Progesterone
Comments/Corrections

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