Document Detail


Pregnancy and pharmacogenomics in the context of drug metabolism and response.
MedLine Citation:
PMID:  24192125     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
It is well-known that profound physiological and biochemical changes occur throughout the course of pregnancy. At the same time, the role of pharmacogenomics in modulating the metabolism and response profile to numerous medications has been elucidated. Yet, the clinical impact of pharmacogenomics during pregnancy is less well understood. We present an overview of factors modulating the pharmacokinetics and pharmacodynamics of medications throughout the time span of pregnancy while providing insights on how pharmacogenomics may contribute to interindividual variability in drug metabolism and response amongst pregnant women.
Authors:
Anders Helldén; Parvaz Madadi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pharmacogenomics     Volume:  14     ISSN:  1744-8042     ISO Abbreviation:  Pharmacogenomics     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-06     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100897350     Medline TA:  Pharmacogenomics     Country:  England    
Other Details:
Languages:  eng     Pagination:  1779-91     Citation Subset:  IM    
Affiliation:
Division of Clinical Pharmacology & Toxicology, Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, M5G 1X8, Canada.
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