Document Detail

Pregnancy and perinatal outcomes after assisted reproduction: a comparative study.
MedLine Citation:
PMID:  18521653     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Increasing use of fertility therapy has elicited concerns regarding adverse effects for expectant mothers and the health of children thus conceived. AIMS: To study the risk of adverse perinatal outcomes, birth defects and pregnancy complications following assisted reproductive technology (ART). METHODS: Questionnaire-based study involving 1,524 children and 1,182 pregnancies conceived following in vitro fertilisation (IVF) in two units. Outcomes were compared with the general population. RESULTS: In the study group versus the general population; multi-foetal gestations, 26 versus 2%; singleton preterm delivery and low birth weight, 8.7 and 6.4 versus 4.3 and 4%, respectively; non-lethal congenital malformation rate, 2.6 versus 2.1%; placenta praevia, 2.8 versus 0.5%. CONCLUSIONS: Multi-foetal gestations remain the principal cause of adverse perinatal outcomes after ART. Singleton ART pregnancies have an increased risk of preterm delivery and low birth weight at term. Non-lethal congenital malformation rates are not increased following ART. Placenta praevia is increased following ART.
C Allen; S Bowdin; R F Harrison; A G Sutcliffe; L Brueton; G Kirby; J Kirkman-Brown; C Barrett; W Reardon; E Maher
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Publication Detail:
Type:  Comparative Study; Journal Article; Multicenter Study     Date:  2008-06-03
Journal Detail:
Title:  Irish journal of medical science     Volume:  177     ISSN:  1863-4362     ISO Abbreviation:  Ir J Med Sci     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-07-29     Completed Date:  2008-10-09     Revised Date:  2009-05-21    
Medline Journal Info:
Nlm Unique ID:  7806864     Medline TA:  Ir J Med Sci     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  233-41     Citation Subset:  IM    
Human Assisted Reproduction Ireland, Rotunda Hospital, Dublin, Ireland.
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MeSH Terms
Chi-Square Distribution
Congenital Abnormalities / epidemiology,  etiology
Infant, Low Birth Weight
Infant, Newborn
Ireland / epidemiology
Placenta Previa / epidemiology,  etiology
Pregnancy Complications / epidemiology*,  etiology*
Pregnancy Outcome*
Pregnancy, Multiple
Premature Birth / epidemiology,  etiology
Reproductive Techniques, Assisted / adverse effects*
Risk Factors
Comment In:
Ir J Med Sci. 2009 Mar;178(1):119   [PMID:  19020923 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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