Document Detail


Pregnancy outcomes with increased clomiphene citrate dose.
MedLine Citation:
PMID:  15697075     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Our objective was to evaluate whether ovulation induction with an increased clomiphene citrate dose of 150-250 mg/day for 5 days adversely affected pregnancy outcome. A retrospective chart review of 1910 medical records yielded 119 pregnancies with sufficient information regarding domiphene dose and pregnancy outcome. Of the 84 pregnancies that followed clomiphene doses of 50-100 mg/day, 32.1% ended in spontaneous abortion, 10.7% in ectopic gestation, 1.2% with congenital malformations, 2.4% in stillbirth and 53.6% in normal gestation. Of the 35 pregnancies that followed clomiphene doses of 150-250 mg/day, 34.3% ended in spontaneous abortion, 5.7% in ectopic gestation, 2.9% with congenital malformations, 2.9% in stillbirth and 54.3% in normal gestation. These differences were not statistically significant. These data suggest that a clomiphene dose of 150-250 mg/day does not appear to increase adverse pregnancy outcomes.
Authors:
J K Jain; J Kuo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology     Volume:  19     ISSN:  0951-3590     ISO Abbreviation:  Gynecol. Endocrinol.     Publication Date:  2004 Sep 
Date Detail:
Created Date:  2005-02-08     Completed Date:  2005-03-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  8807913     Medline TA:  Gynecol Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Affiliation:
Department of Obstetrics and Gynecology, Keck School of Medicine, University of Southern California, Women's and Children's Hospital, Los Angeles, CA 90033, USA.
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MeSH Terms
Descriptor/Qualifier:
Abortion, Spontaneous / epidemiology
Clomiphene / administration & dosage*
Congenital Abnormalities / epidemiology
Female
Humans
Ovulation Induction*
Pregnancy
Pregnancy Outcome* / epidemiology
Pregnancy, Ectopic / epidemiology
Chemical
Reg. No./Substance:
911-45-5/Clomiphene

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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